Protective effect of red wine on oxidative stress and antioxidant enzyme activities in the brain and kidney induced by feeding high cholesterol in rats

The effect of red wine (400 ml/70 kg) on brain and kidney oxidative stress and antioxidative enzymes activities induced by cholesterol-enriched diet (supplemented with 1.65% of cholesterol (w/w) for 4 weeks) was studied in rats. When red wine (Montilla-Moriles, Cordoba, Spain) was simultaneously sup...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2006-02, Vol.25 (1), p.146-153
Main Authors: Montilla, Pedro, Espejo, Isabel, Muñoz, Maria C., Bujalance, Inmaculada, Muñoz-Castañeda, Juan R., Tunez, Isaac
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Biological and medical sciences
Brain - enzymology
Catalase - metabolism
Cholesterol
Cholesterol, Dietary - administration & dosage
Cholesterol, Dietary - pharmacology
Disorders of blood lipids. Hyperlipoproteinemia
Female
Glutathione Peroxidase - metabolism
Hypercholesterolemia
Hypercholesterolemia - metabolism
Kidney - enzymology
Lipid Peroxidation - drug effects
Medical sciences
Metabolic diseases
Oxidative stress
Oxidative Stress - drug effects
Random Allocation
Rats
Rats, Wistar
Red wine
Superoxide Dismutase - metabolism
Wine
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Summary:The effect of red wine (400 ml/70 kg) on brain and kidney oxidative stress and antioxidative enzymes activities induced by cholesterol-enriched diet (supplemented with 1.65% of cholesterol (w/w) for 4 weeks) was studied in rats. When red wine (Montilla-Moriles, Cordoba, Spain) was simultaneously supplemented to high-cholesterol diet for 4 weeks, total cholesterol and lipid peroxidation products in the brain, kidney and erythrocytes significantly decreased compared with the high-cholesterol, while GSH content and antioxidative enzymes activities enhanced. On the other hand, the urinary excretion of urea, creatinine and albumin decreased significantly. These results suggest that red wine may have a neuro–nephroprotective effect against oxidative stress and hypercholesterolemia.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2005.10.004