Comparison of coronary angiography findings in diabetic and non-diabetic women with non-ST-segment-elevation acute coronary syndrome

• Published in: Arquivos brasileiros de cardiologia 2006-02, Vol.86 (2), p.150-155
• Main Authors: Sousa, José Marconi Almeida de, Herrman, João L V, Teodoro, Marco, Diogo, Sergio, Terceiro, Bernardino Bandeira, Paola, Angelo Amato Vincenzo de, Carvalho, Antonio Carlos Camargo
• Format: Article
• Language: eng ; por
• Subjects: Angina, Unstable - diagnostic imaging; Angina, Unstable - etiology; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Diabetic Angiopathies - diagnostic imaging; Female; Heart Conduction System - diagnostic imaging; Humans; Middle Aged; Prospective Studies
• ISSN: 0066-782X
• DOI: 10.1590/s0066-782x2006000200012

Compare hemodynamic and angiographic patterns, as well as atherosclerotic lesion morphology, in diabetic and non-diabetic females with unstable angina or non-ST-segment-elevation myocardial infarction (UA/NSTEMI). Two interventional cardiologists determined the presence of severe atherosclerotic lesion, defined as those > or = 70%; plaque morphology, according to the American Heart Association classification; collateral circulation; plus ventricular and aortic pressures. Ejection fraction was calculated by angiography or echocardiography. During eight and a half years, 645 coronary angiographies were performed in women with UA/NSTEMI. In the present study, 593 female patients were assessed (215 diabetic--36%). This group differed from the non-diabetic in the following aspects: older age (61 +/- 10.6 x 58.1 +/- 11.4), higher prevalence of postmenopausal women and lower prevalence of the smoking habit. Severe three-vessel disease was significantly more frequent in diabetic patients (28% x 10%), as well as totally occluded vessels: 51 (23%) x 54 (14.3%), p < 0.005. Additionally, ejection fraction < 50% was more common in diabetic patients. These findings confirm the diffuse pattern of atherosclerotic disease in diabetic patients, as well a greater deterioration of ventricular function, which may be associated to the poorer prognosis seen in this population both in the short- and long-term.