Cytotoxic Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella globostellata

Fourteen isomalabaricane triterpenes were isolated from the marine sponge Rhabdastrella globostellata. In addition to the known compounds globostellatic acids A (1) and D (4) and stelliferin riboside (13), 11 of the compounds were new natural products, which included globostelletin (3), eight new gl...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-02, Vol.69 (2), p.211-218
Main Authors: Fouad, Mostafa, Edrada, Ru Angelie, Ebel, Rainer, Wray, Victor, Müller, Werner E. G, Lin, Wen Han, Proksch, Peter
Format: Article
Language:English
Subjects:
animal health
Animals
anticarcinogenic activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
chemical structure
cultured cells
cytotoxicity
Drug Screening Assays, Antitumor
General pharmacology
HeLa Cells
human health
Humans
Indonesia
isomalabaricane
Marine
Medical sciences
Mice
Molecular Structure
PC12 Cells
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
Porifera - chemistry
Rats
Rhabdastrella globostellata
spectral analysis
stereochemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
Tumor Cells, Cultured
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Summary:Fourteen isomalabaricane triterpenes were isolated from the marine sponge Rhabdastrella globostellata. In addition to the known compounds globostellatic acids A (1) and D (4) and stelliferin riboside (13), 11 of the compounds were new natural products, which included globostelletin (3), eight new globostellatic acid congeners, F to M (2, 5−11), and two new stelliferin ribosides (12 and 14). The isolated compounds were tested against three different cancer cell lines, L5178Y (mouse lymphoma), HeLa (human cervix carcinoma), and PC-12 (rat pheochromocytoma). The isomalabaricane derivatives were found to be selectively active toward the mouse lymphoma cell line L5178Y. The structures were determined by 1D and 2D NMR data and by comparison with spectroscopic data of known related compounds.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050346t