CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations

Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional ca...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2006-03, Vol.24 (2), p.132-137
Main Authors: HUANG, Qing-Yang, HUI SHEN, DENG, Hong-Yi, CONWAY, Theresa, ELZE, Leo, DAVIES, K. Michael, RECKER, Robert R, DENG, Hong-Wen
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Bone Density
Bones
Diseases of the osteoarticular system
European Continental Ancestry Group
Family Health
Female
Genetic Linkage
Genome
Genotype
Humans
Investigative techniques, diagnostic techniques (general aspects)
Linkage Disequilibrium
Male
Medical sciences
Middle Aged
Models, Statistical
Older people
Osteoarticular system. Muscles
Osteoporosis - genetics
Pedigree
Phenotype
Polymorphism, Genetic
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Receptors, Tumor Necrosis Factor, Type II - genetics
Receptors, Tumor Necrosis Factor, Type II - physiology
Spine - metabolism
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Summary:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in osteoporosis. In this study, we conducted linkage and association tests between the CA repeat polymorphism of the TNFR2 gene and BMD in two large independent samples using the quantitative transmission disequilibrium test (QTDT) program. The first group of subjects was composed of 1836 individuals from 79 multigeneration pedigrees. The second group was a randomly ascertained set of 636 individuals from 157 nuclear families. We found no evidence of association or linkage for spine or hip BMD in the samples of the multigenerational pedigrees or nuclear families. Through testing for association and for linkage, our data do not support the TNFR2 gene as a QTL underlying hip or spine BMD variation in our Caucasian populations.
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-005-0659-7