Neuropeptide-Y Y2-receptor agonist, PYY3-36 promotes non-rapid eye movement sleep in rat

PYY3-36 is a major component of the gut-brain axis and peripheral administration has been reported to exert significant effects on feeding, brain function and is more selective for neuropeptide Y2 receptor. Therefore, we investigated the effects of nocturnal intraperitoneal administration of single...

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Bibliographic Details
Published in:Neuroscience research 2006-03, Vol.54 (3), p.165-170
Main Authors: Akanmu, Moses A, Ukponmwan, Otas E, Katayama, Yoshifumi, Honda, Kazuki
Format: Article
Language:English
Subjects:
Animals
Drinking - drug effects
Eating - drug effects
Electroencephalography
Electromyography
Feeding Behavior - drug effects
Male
Peptide Fragments
Peptide YY - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Neuropeptide Y - agonists
Sleep - drug effects
Wakefulness - drug effects
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Summary:PYY3-36 is a major component of the gut-brain axis and peripheral administration has been reported to exert significant effects on feeding, brain function and is more selective for neuropeptide Y2 receptor. Therefore, we investigated the effects of nocturnal intraperitoneal administration of single doses of PYY3-36 (30 and 100 microg/kg i.p.) on food intake, water intake and the sleep-wake cycle in rats. Sleep recordings were carried out in male Sprague-Dawley rats implanted with cortical electroencephalogram (EEG) and neck electromyogram (EMG) electrodes. The EEG, EMG, food intake and water intake were assessed. The electrographic recordings obtained were scored visually as rapid eye movement (REM) sleep, non-REM (NREM) sleep and wakefulness. PYY3-36 administration 15 min prior to dark onset significantly (p
ISSN:0168-0102
DOI:10.1016/j.neures.2005.11.006