Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men

• Published in: International Journal of Obesity 2006-03, Vol.30 (3), p.460-467
• Main Authors: Sundell, J, Laine, H, Nuutila, P, Luotolahti, M, Knuuti, J
• Format: Article
• Language: English
• Subjects: Adenosine; Adenosine - pharmacology; Adult; Anti-Inflammatory Agents - pharmacology; Atherosclerosis; Biological and medical sciences; Blood Glucose - metabolism; Blood pressure; Body mass index; C-Reactive Protein - drug effects; C-Reactive Protein - metabolism; C-Reactive Protein - physiology; Cardiology. Vascular system; Cardiovascular disease; Cholesterol; Coronary Circulation; Coronary heart disease; Coronary vessels; Coronary Vessels - diagnostic imaging; Dexamethasone - pharmacology; Emissions; Endothelium; Epidemiology; Fatty Acids, Nonesterified - blood; Glucose Clamp Technique; Health Promotion and Disease Prevention; Heart; Hemodynamics - drug effects; High density lipoprotein; Humans; Insulin; Insulin - blood; Internal Medicine; Low density lipoprotein; Male; Males; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Obesity; Obesity - blood; Obesity - diagnostic imaging; Obesity - physiopathology; original-article; Positron-Emission Tomography; Proteins; Public Health; Tomography; Vascular Resistance - drug effects; Vein & artery diseases; Weight control
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0803164

Aim: Obese subjects are characterized by increased high-sensitivity C-reactive protein (hsCRP) and coronary vascular resistance. Clucocorticoids suppress inflammation, a possible cardioprotective effect. We tested the short-term anti-inflammatory effect of dexamethasone (dx) on these parameters in obese subjects. Methods: Coronary vascular resistance was quantitated basally and during adenosine infusion with or without simultaneous euglycemic hyperinsulinemic clamp (insulin infusion rate of 1 mU/kg/min) in 11 obese and 19 age-matched nonobese males using positron emission tomography and 15 O-water. Each subject was studied both with and without previous dx treatment for 2 days (2 mg/day). Results: Before dx treatment, hsCRP concentration was significantly higher in obese than in nonobese subjects (1.55±1.73 vs 0.32±0.32 mg/l, P =0.005). In addition, coronary vascular resistances were higher ( P