The discovery of the human chromosome number in Lund, 1955-1956

The correct determination of the human diploid chromosome number as 46, by J-H Tjio and A Levan, at the University of Lund, Sweden, occurred 50 years ago, in December 1955; the finding was published in April 1956, ending a period of more than 30 years when the number had been thought to be 48. The b...

Full description

Saved in:
Bibliographic Details
Published in:Human genetics 2006-03, Vol.119 (1-2), p.226-232
Main Author: HARPER, Peter S
Format: Article
Language:English
Subjects:
Albert Levan
Biological and medical sciences
Chromosome Disorders - diagnosis
Chromosome Disorders - genetics
Chromosomes, Human - genetics
Classical genetics, quantitative genetics, hybrids
Cytogenetic Analysis - history
Cytogenetic Analysis - methods
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genetics, Medical - history
History, 20th Century
Human
Humans
Joe-Hin Tjio
Karyotyping
Levan
Sweden
Tjio
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3
cites cdi_FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3
container_end_page 232
container_issue 1-2
container_start_page 226
container_title Human genetics
container_volume 119
creator HARPER, Peter S
description The correct determination of the human diploid chromosome number as 46, by J-H Tjio and A Levan, at the University of Lund, Sweden, occurred 50 years ago, in December 1955; the finding was published in April 1956, ending a period of more than 30 years when the number had been thought to be 48. The background to the discovery and the surrounding factors are reassessed, as are the reasons why previous investigators persistently misidentified the precise number. The necessity for multiple technological advances, the power of previously accepted conclusions in influencing the interpretation of later results, and the importance of other work already undertaken in Lund, are all relevant factors for the occurrence of this discovery, the foundation for modern human cytogenetics, at this particular time and place.
doi_str_mv 10.1007/s00439-005-0121-x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67698016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>995358851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3</originalsourceid><addsrcrecordid>eNpdkU1LAzEQhoMotn78AC-yCHoyOkl2kuYkUvyCghc9h-xuQrd0NzXpiv33RlooeJmB4ZmX4RlCLhjcMQB1nwBKoSkAUmCc0Z8DMmal4JRxEIdkDKIEKhVTI3KS0gKAoeZ4TEZMllIAxzF5-Ji7omlTHb5d3BTBF-s8mA-d7Yt6HkMXUuhc0Q9d5WLR9sVs6JvbgmlEmos8I0feLpM73_VT8vn89DF9pbP3l7fp44zWAuWaVg6ritfCg2S-lKDQc4kwAZ2DnCobxbi0UqH2CkE3JffaAiplpfTae3FKbra5qxi-BpfWpstHu-XS9i4MyUgl9QSYzODVP3ARhtjn2wxniCUInGSIbaE6hpSi82YV287GjWFg_tSarVqT1Zo_teYn71zugoeqc81-Y-cyA9c7wKbaLn20fd2mPadwgvkv4he8Fnzs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215540358</pqid></control><display><type>article</type><title>The discovery of the human chromosome number in Lund, 1955-1956</title><source>Springer Nature</source><creator>HARPER, Peter S</creator><creatorcontrib>HARPER, Peter S</creatorcontrib><description>The correct determination of the human diploid chromosome number as 46, by J-H Tjio and A Levan, at the University of Lund, Sweden, occurred 50 years ago, in December 1955; the finding was published in April 1956, ending a period of more than 30 years when the number had been thought to be 48. The background to the discovery and the surrounding factors are reassessed, as are the reasons why previous investigators persistently misidentified the precise number. The necessity for multiple technological advances, the power of previously accepted conclusions in influencing the interpretation of later results, and the importance of other work already undertaken in Lund, are all relevant factors for the occurrence of this discovery, the foundation for modern human cytogenetics, at this particular time and place.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-005-0121-x</identifier><identifier>PMID: 16463025</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Albert Levan ; Biological and medical sciences ; Chromosome Disorders - diagnosis ; Chromosome Disorders - genetics ; Chromosomes, Human - genetics ; Classical genetics, quantitative genetics, hybrids ; Cytogenetic Analysis - history ; Cytogenetic Analysis - methods ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Genetics, Medical - history ; History, 20th Century ; Human ; Humans ; Joe-Hin Tjio ; Karyotyping ; Levan ; Sweden ; Tjio</subject><ispartof>Human genetics, 2006-03, Vol.119 (1-2), p.226-232</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3</citedby><cites>FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17585203$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16463025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARPER, Peter S</creatorcontrib><title>The discovery of the human chromosome number in Lund, 1955-1956</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>The correct determination of the human diploid chromosome number as 46, by J-H Tjio and A Levan, at the University of Lund, Sweden, occurred 50 years ago, in December 1955; the finding was published in April 1956, ending a period of more than 30 years when the number had been thought to be 48. The background to the discovery and the surrounding factors are reassessed, as are the reasons why previous investigators persistently misidentified the precise number. The necessity for multiple technological advances, the power of previously accepted conclusions in influencing the interpretation of later results, and the importance of other work already undertaken in Lund, are all relevant factors for the occurrence of this discovery, the foundation for modern human cytogenetics, at this particular time and place.</description><subject>Albert Levan</subject><subject>Biological and medical sciences</subject><subject>Chromosome Disorders - diagnosis</subject><subject>Chromosome Disorders - genetics</subject><subject>Chromosomes, Human - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cytogenetic Analysis - history</subject><subject>Cytogenetic Analysis - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genetics, Medical - history</subject><subject>History, 20th Century</subject><subject>Human</subject><subject>Humans</subject><subject>Joe-Hin Tjio</subject><subject>Karyotyping</subject><subject>Levan</subject><subject>Sweden</subject><subject>Tjio</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LAzEQhoMotn78AC-yCHoyOkl2kuYkUvyCghc9h-xuQrd0NzXpiv33RlooeJmB4ZmX4RlCLhjcMQB1nwBKoSkAUmCc0Z8DMmal4JRxEIdkDKIEKhVTI3KS0gKAoeZ4TEZMllIAxzF5-Ji7omlTHb5d3BTBF-s8mA-d7Yt6HkMXUuhc0Q9d5WLR9sVs6JvbgmlEmos8I0feLpM73_VT8vn89DF9pbP3l7fp44zWAuWaVg6ritfCg2S-lKDQc4kwAZ2DnCobxbi0UqH2CkE3JffaAiplpfTae3FKbra5qxi-BpfWpstHu-XS9i4MyUgl9QSYzODVP3ARhtjn2wxniCUInGSIbaE6hpSi82YV287GjWFg_tSarVqT1Zo_teYn71zugoeqc81-Y-cyA9c7wKbaLn20fd2mPadwgvkv4he8Fnzs</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>HARPER, Peter S</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>The discovery of the human chromosome number in Lund, 1955-1956</title><author>HARPER, Peter S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Albert Levan</topic><topic>Biological and medical sciences</topic><topic>Chromosome Disorders - diagnosis</topic><topic>Chromosome Disorders - genetics</topic><topic>Chromosomes, Human - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Cytogenetic Analysis - history</topic><topic>Cytogenetic Analysis - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genetics, Medical - history</topic><topic>History, 20th Century</topic><topic>Human</topic><topic>Humans</topic><topic>Joe-Hin Tjio</topic><topic>Karyotyping</topic><topic>Levan</topic><topic>Sweden</topic><topic>Tjio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARPER, Peter S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARPER, Peter S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The discovery of the human chromosome number in Lund, 1955-1956</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>119</volume><issue>1-2</issue><spage>226</spage><epage>232</epage><pages>226-232</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>The correct determination of the human diploid chromosome number as 46, by J-H Tjio and A Levan, at the University of Lund, Sweden, occurred 50 years ago, in December 1955; the finding was published in April 1956, ending a period of more than 30 years when the number had been thought to be 48. The background to the discovery and the surrounding factors are reassessed, as are the reasons why previous investigators persistently misidentified the precise number. The necessity for multiple technological advances, the power of previously accepted conclusions in influencing the interpretation of later results, and the importance of other work already undertaken in Lund, are all relevant factors for the occurrence of this discovery, the foundation for modern human cytogenetics, at this particular time and place.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>16463025</pmid><doi>10.1007/s00439-005-0121-x</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0340-6717
ispartof Human genetics, 2006-03, Vol.119 (1-2), p.226-232
issn 0340-6717
1432-1203
language eng
recordid cdi_proquest_miscellaneous_67698016
source Springer Nature
subjects Albert Levan
Biological and medical sciences
Chromosome Disorders - diagnosis
Chromosome Disorders - genetics
Chromosomes, Human - genetics
Classical genetics, quantitative genetics, hybrids
Cytogenetic Analysis - history
Cytogenetic Analysis - methods
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genetics, Medical - history
History, 20th Century
Human
Humans
Joe-Hin Tjio
Karyotyping
Levan
Sweden
Tjio
title The discovery of the human chromosome number in Lund, 1955-1956
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A39%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20discovery%20of%20the%20human%20chromosome%20number%20in%20Lund,%201955-1956&rft.jtitle=Human%20genetics&rft.au=HARPER,%20Peter%20S&rft.date=2006-03-01&rft.volume=119&rft.issue=1-2&rft.spage=226&rft.epage=232&rft.pages=226-232&rft.issn=0340-6717&rft.eissn=1432-1203&rft.coden=HUGEDQ&rft_id=info:doi/10.1007/s00439-005-0121-x&rft_dat=%3Cproquest_cross%3E995358851%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-be5bb2c3f061f46075f2650809955e74d7126a6759f7509d42f9a0577a66f9ff3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=215540358&rft_id=info:pmid/16463025&rfr_iscdi=true