The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats

Free-feeding rats meet much of their daily energy requirements by consuming food in meals during the nocturnal phase of the night/day cycle. Meal pattern analysis methodology has been developed to record the patterns of meal taken over a 24-h period, and to provide detailed information on a number o...

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Bibliographic Details
Published in:European journal of pharmacology 2006-02, Vol.532 (3), p.253-257
Main Authors: COOPER, Steven J, AL-NASER, Hessah A, CLIFTON, Peter G
Format: Article
Language:English
Subjects:
Adamantane - analogs & derivatives
Adamantane - pharmacology
Animals
Appetite Depressants - pharmacology
Benzopyrans - pharmacology
Biological and medical sciences
Circadian Rhythm
Dopamine Agonists - pharmacology
Dose-Response Relationship, Drug
Eating - drug effects
Feeding Behavior - drug effects
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Receptors, Dopamine D1 - agonists
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Summary:Free-feeding rats meet much of their daily energy requirements by consuming food in meals during the nocturnal phase of the night/day cycle. Meal pattern analysis methodology has been developed to record the patterns of meal taken over a 24-h period, and to provide detailed information on a number of meal-related parameters. Previous work indicates that selective dopamine D1-receptor agonists reduce food intake in short-term feeding tests under the control of homeostatic or hedonic factors. In the present study, our aim was to investigate the effects of the dopamine D1-receptor agonist, A-77636 (0.1-1.0 mg/kg, s.c.), administered just prior to the start of the night period, on the free-feeding and drinking patterns of rats maintained on a standard ad libitum diet. The results indicate that A-77636 exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration. We conclude that there is a dopamine D1-receptor involvement in the normal controls of meal size, and that selective D1-receptor agonists may act to limit meal size.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2005.11.046