Commercial cows' milk has uterotrophic activity on the uteri of young ovariectomized rats and immature rats

Cows' milk contains considerable quantities of estrogens, mainly in the form of estrone sulfate (ES). To determine whether the commercial milk has any biologically significant hormonal effects, 2 series of uterotrophic tests were performed, 1 with young ovariectomized rats and the other with se...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2006-05, Vol.118 (9), p.2363-2365
Main Authors: Ganmaa, Davaasambuu, Tezuka, Hideo, Enkhmaa, Davaasambuu, Hoshi, Kazuhiko, Sato, Akio
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Proliferation
cows'milk
Diet
Estrone - analogs & derivatives
Estrone - pharmacology
Female
immature rats
Medical sciences
Milk - chemistry
ovariectomized rats
Ovariectomy
positive uterotrophic test
Rats
Rats, Wistar
Sexual Maturation
Tumors
Uterus - anatomy & histology
Uterus - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cows' milk contains considerable quantities of estrogens, mainly in the form of estrone sulfate (ES). To determine whether the commercial milk has any biologically significant hormonal effects, 2 series of uterotrophic tests were performed, 1 with young ovariectomized rats and the other with sexually immature rats. Thirty‐six rats were used for each test. They were divided into 3 groups of 12 animals each, and were kept for 7 days on powdered chow with 1 of 3 drinking solutions: low‐fat milk (LFM), artificial milk (AM, negative control), or AM containing ES at 100 ng/ml (positive control). At autopsy, both the wet and blotted uterine weights were measured. The cell heights of uterine epithelia in ovariectomized rats were also determined. The significance of differences among groups was tested by Dunnett's multiple comparisons test. In each test, the weights of the uteri in the LFM group were significantly greater than those of the respective weights in the AM group (p < 0.01). Furthermore, in ovariectomized rats, the uterine epithelial‐cell height in the LFM group was significantly greater than that observed in the AM group (p < 0.01). The uterotrophic effect of 100 ng/ml ES solution was greater than that of LFM in immature rats (p < 0.01), whereas the effect of the solution was almost comparable to that of LFM in young ovariectomized rats (p > 0.05). In conclusion, commercially available milk has uterotrophic effects in both young ovariectomized rats and sexually immature rats. © 2005 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.21659