Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia

Morphogenetic factors have been shown to play a role in embryogenesis and post-embryonic disease. Interstitial pulmonary fibrosis is a chronic and often progressive disorder that can lead to end-stage cystic lung. Its two major subtypes, usual interstitial pneumonitis (UIP) and nonspecific interstit...

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Bibliographic Details
Published in:Experimental and molecular pathology 2006-04, Vol.80 (2), p.119-123
Main Authors: Coon, David R., Roberts, Drucilla J., Loscertales, Maria, Kradin, Richard
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Case-Control Studies
Epithelial Cells - metabolism
Epithelial Cells - pathology
Female
Forkhead Transcription Factors - genetics
Foxf1
Gene Expression Profiling
Gene Expression Regulation
Hedgehog Proteins
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lung - pathology
Lung Diseases, Interstitial - genetics
Male
Medical sciences
Middle Aged
Nonspecific interstitial pneumonia
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pneumology
Pulmonary fibrosis
Respiratory system : syndromes and miscellaneous diseases
Sonic hedgehog
Trans-Activators - genetics
Usual interstitial pneumonia
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Summary:Morphogenetic factors have been shown to play a role in embryogenesis and post-embryonic disease. Interstitial pulmonary fibrosis is a chronic and often progressive disorder that can lead to end-stage cystic lung. Its two major subtypes, usual interstitial pneumonitis (UIP) and nonspecific interstitial pneumonitis (NSIP) differ in their response to immunosuppressive regimens, with UIP having a significantly worse prognosis. The clinical and histologic overlap between these disorders is substantial, and there are no ancillary findings that can accurately distinguish them. We examined surgical and autopsy specimens of lung in 13 cases of patients with either UIP or the fibrotic variant of NSIP (NSIP-F) for their expression of Sonic hedgehog (Shh) and Foxf1 in situ. We identified a pattern of strong Shh expression with weak expression of Foxf1 in all cases of UIP and a complementary expression of Shh and Foxf1 in cases of NSIP-F. We conclude that morphogenetic genes may participate differentially in the pathogenesis of UIP and NSIP-F.
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2005.12.003