The effect of methylprednisolone treatment on cerebral reactivity in patients with multiple sclerosis

We assessed the effect of intravenous high-dose methylprednisolone (IVMP) on cerebral reactivity in multiple sclerosis (MS) patients during exacerbations by means of functional transcranial Doppler imaging. Forty-eight clinically defined MS patients were evaluated with visual evoked potentials (VEP)...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2006-02, Vol.13 (2), p.214-217
Main Authors: Özkan, Serhat, Uzuner, Nevzat, Kutlu, Ceyhan, Özbabalık, Demet, Özdemir, Gazi
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Cerebral reactivity
Evoked Potentials, Visual - drug effects
Evoked Potentials, Visual - physiology
Female
Humans
Injections, Intravenous
Male
Methylprednisolone
Methylprednisolone - administration & dosage
Methylprednisolone - therapeutic use
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - drug therapy
Transcranial Doppler
Ultrasonography, Doppler, Transcranial
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Summary:We assessed the effect of intravenous high-dose methylprednisolone (IVMP) on cerebral reactivity in multiple sclerosis (MS) patients during exacerbations by means of functional transcranial Doppler imaging. Forty-eight clinically defined MS patients were evaluated with visual evoked potentials (VEP) and functional transcranial Doppler sonography (TCD) of both posterior cerebral arteries before and after 5 days of 1000 mg IVMP. After treatment, mean Expanded Disability Status Scale score, mean blood flow velocities and mean blood flow velocities at rest and at stimulation, significantly decreased ( p < 0.0001, for each). The change in cerebral blood flow velocity ratio (CBFv) with visual stimulation after treatment increased slightly ( p = 0.20). All TCD parameters were not significantly correlated with VEP changes. In conclusion, we observed significant changes in CBFv with a non-significant increase in vascular reactivity after treatment with IVMP in exacerbations of MS. Case-control studies are necessary to draw conclusions regarding the beneficial effects of IVMP treatment.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2005.03.023