Protein targeting by the bacterial twin-arginine translocation (Tat) pathway

The Tat (twin-arginine translocation) protein export system is found in the cytoplasmic membrane of most prokaryotes and is dedicated to the transport of folded proteins. The Tat system is now known to be essential for many bacterial processes including energy metabolism, cell wall biosynthesis, the...

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Bibliographic Details
Published in:Current opinion in microbiology 2005-04, Vol.8 (2), p.174-181
Main Authors: Berks, Ben C, Palmer, Tracy, Sargent, Frank
Format: Article
Language:English
Subjects:
Bacteria - metabolism
Bacterial Proteins - metabolism
Escherichia coli - metabolism
Escherichia coli Proteins - physiology
Membrane Transport Proteins - physiology
Protein Transport
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Summary:The Tat (twin-arginine translocation) protein export system is found in the cytoplasmic membrane of most prokaryotes and is dedicated to the transport of folded proteins. The Tat system is now known to be essential for many bacterial processes including energy metabolism, cell wall biosynthesis, the nitrogen-fixing symbiosis and bacterial pathogenesis. Recent studies demonstrate that substrate-specific accessory proteins prevent improperly assembled substrates from interacting with the Tat transporter. During the transport cycle itself substrate proteins bind to a receptor complex in the membrane which then recruits a protein-translocating channel to carry out the transport reaction.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2005.02.010