Anti-diabetic Activity of SMK001, a Poly Herbal Formula in Streptozotocin Induced Diabetic Rats: Therapeutic Study

The therapeutic anti-diabetic effect of SMK001, a poly herbal formula was evaluated in the streptozotocin (STZ; 60 mg/kg, single intraperitoneal injection) induced diabetic rats. For therapeutic study, test articles were orally dosed once a day from 21 d after STZ-dosing at 100, 200 and 500 mg/kg/5...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2006, Vol.29(3), pp.477-482
Main Authors: Kim, Jong Dae, Kang, Seock Man, Seo, Bu Il, Choi, Hae Yun, Choi, Hong Sik, Ku, Sae Kwang
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Body Weight - drug effects
Chinese herbal formula
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - pathology
Dose-Response Relationship, Drug
Drugs, Chinese Herbal
Female
Glucagon - metabolism
glucose
Glyburide - therapeutic use
Glycosuria - metabolism
histopathology
Hypoglycemic Agents - therapeutic use
Immunohistochemistry
Insulin - biosynthesis
Organ Size - drug effects
pancreas
Pancreas - cytology
Pancreas - drug effects
Pancreas - pathology
Plant Extracts - therapeutic use
Rats
Rats, Sprague-Dawley
streptozotocin
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Summary:The therapeutic anti-diabetic effect of SMK001, a poly herbal formula was evaluated in the streptozotocin (STZ; 60 mg/kg, single intraperitoneal injection) induced diabetic rats. For therapeutic study, test articles were orally dosed once a day from 21 d after STZ-dosing at 100, 200 and 500 mg/kg/5 ml dosage levels for 4 weeks. The body weight changes, blood and urine glucose level changes were monitored with changes on the pancreas weight, and after sacrifice, the histopathological changes of pancreas and the changes of insulin- and glucagon-producing cells were also observed by immunohistochemistry. The results were compared to that of glibenclamide 5 mg/kg-dosing group. Significantly (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.477