Intramuscular triamcinolone for difficult asthma

• Published in: Pediatric pulmonology 2005-05, Vol.39 (5), p.421-425
• Main Authors: Panickar, Jayachandran R., Kenia, Priti, Silverman, Michael, Grigg, Jonathan
• Format: Article
• Language: English
• Subjects: Adolescent; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - therapeutic use; Asthma - drug therapy; Asthma - physiopathology; Biological and medical sciences; Biomarkers - analysis; Bones, joints and connective tissue. Antiinflammatory agents; Child; Child, Preschool; Chronic obstructive pulmonary disease, asthma; difficult asthma; Female; Follow-Up Studies; Glucocorticoids - administration & dosage; Glucocorticoids - therapeutic use; Humans; Injections, Intramuscular; intramuscular triamcinolone; Male; Medical sciences; oral steroids; Patient Admission; Pharmacology. Drug treatments; Pneumology; Prednisolone - therapeutic use; Retrospective Studies; Time Factors; Treatment Outcome; Triamcinolone Acetonide - administration & dosage
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.20176

We treated a selected group of children attending a difficult asthma clinic with intramuscular triamcinolone acetonide. This study retrospectively reviews markers of asthma severity in those who received one or more monthly doses for three periods: 1) 3 months preceding the first injection (pretreatment), 2) from the first injection to 1 month after the last injection (treatment period), and 3) 3 months after the treatment period (follow‐up period). Severity markers during the treatment and follow‐up periods were compared with the pretreatment period by paired t‐test. Five children (5–13 years old) received a single dose, and 8 children (12–15 years old) received multiple doses. Multiple doses of triamcinolone (n = 3–5) were associated with a fall in the number of asthma exacerbations (P