How far can the antigen content of tissue culture rabies vaccine be reduced safely?

[...]this seemed to be a much more appropriate way of diluting the vaccine than using water as proposed by Hemachuda and Wilde, as dilution with water changes the physico-chemical properties of the finally injected solution and - especially in the highest dilution - might lead to a significant incre...

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Bibliographic Details
Published in:Vaccine 2006-03, Vol.24 (13), p.2223-2224
Main Authors: Beran, Jiri, Honegr, Karel, Banzhoff, Angelika, Malerczyk, Claudius
Format: Article
Language:English
Subjects:
Animals
Antigens
Chemical properties
Chick Embryo
Dilution
Humans
Immunogenicity
Injections, Intradermal
Rabies
Rabies Vaccines - administration & dosage
Rabies Vaccines - adverse effects
Rabies Vaccines - immunology
Vaccines
Vaccines, Synthetic - administration & dosage
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Summary:[...]this seemed to be a much more appropriate way of diluting the vaccine than using water as proposed by Hemachuda and Wilde, as dilution with water changes the physico-chemical properties of the finally injected solution and - especially in the highest dilution - might lead to a significant increase in adverse reactions due to decreased osmolarity and to decreased immunogenicity due to possibly reduced stability.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.12.003