Rice Bran Fractions Improve Blood Pressure, Lipid Profile, and Glucose Metabolism in Stroke-Prone Spontaneously Hypertensive Rats

• Published in: Journal of agricultural and food chemistry 2006-03, Vol.54 (5), p.1914-1920
• Main Authors: Ardiansyah, Shirakawa, Hitoshi, Koseki, Takuya, Ohinata, Kousaku, Hashizume, Katsumi, Komai, Michio
• Format: Article
• Language: English
• Subjects: 8-hydroxy-2'-deoxyguanosine; animal disease models; Animals; Biological and medical sciences; blood chemistry; Blood Glucose - metabolism; blood lipids; Blood Pressure; carbohydrate metabolism; Catechin - analysis; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; deoxyribonucleosides; Diet; dietary supplements; Ethanol; Food industries; food intake; fractionation; Fundamental and applied biological sciences. Psychology; Fungal Proteins; Gallic Acid - analysis; glucose; Glycoside Hydrolases; hypertension; Hypertension - therapy; Lipids - blood; Male; Nitric Oxide - blood; Nitric Oxide - urine; Oryza - chemistry; Rats; Rats, Inbred SHR; rice bran; rice bran fractions; spontaneously hypertensive rats; Stroke; urine
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf052561l

Effect of dietary supplementation of two types of rice bran fraction on blood pressure (BP), lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats was studied. Male 4-week-old rats were divided into one group fed the AIN-93M-based control (C) diet and two groups fed diet supplemented with 60 g/kg of Driselase and ethanol fractions (DF and EF, respectively) of rice bran. After 8 weeks feeding, the BP decreased in the DF and EF groups in comparison with the C group (p < 0.01). Plasma ACE inhibitory activity, BUN, BUN/creatinine ratio, albumin, triglyceride, and glucose levels were lower in the DF and EF groups than in the C group (p < 0.01). Plasma nitric oxide and urinary 8-hydroxy-2‘-deoxyguanosine levels were lower in the DF and EF groups than in the C group (p < 0.01). Rice bran fractions appear to have a beneficial dietary component that improves hypertension, hyperlipidemia, and hyperglycemia. Keywords: Rice bran; Driselase fraction; ethanol fraction; blood pressure; nitric oxide; ACE inhibitory activity; 8-OHdG; lipid profile; glucose level.