Serum levels of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) in acute disseminated encephalomyelitis

In multiple sclerosis, there have been many reports on matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). However, MMPs and TIMPs have not been reported in acute disseminated encephalomyelitis (ADEM). We determined the relationship between the serum concentrations of MMP-9 and TIM...

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Bibliographic Details
Published in:Journal of neuroimmunology 2006-03, Vol.172 (1), p.182-186
Main Authors: Ichiyama, Takashi, Kajimoto, Madoka, Suenaga, Naoko, Maeba, Shinji, Matsubara, Tomoyo, Furukawa, Susumu
Format: Article
Language:English
Subjects:
Acute disseminated encephalomyelitis
Adolescent
Child
Child, Preschool
Encephalomyelitis, Acute Disseminated - blood
Enzyme-Linked Immunosorbent Assay - methods
Female
Humans
Male
Matrix Metalloproteinase 9 - blood
MMP-9
MRI
Statistics, Nonparametric
TIMP-1
Tissue Inhibitor of Metalloproteinase-1 - blood
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Summary:In multiple sclerosis, there have been many reports on matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). However, MMPs and TIMPs have not been reported in acute disseminated encephalomyelitis (ADEM). We determined the relationship between the serum concentrations of MMP-9 and TIMP-1 and activity of lesions on MRI in 14 patients with ADEM to investigate the roles of MMP-9 and TIMP-1 in the pathogenesis of ADEM. Serum MMP-9 and TIMP-1 levels, measured by ELISA and gadolinium-enhanced (Gd+) brain MRI, were analyzed. Serum MMP-9 and TIMP-1 levels at the acute stage were higher than controls, and the serum MMP-9 levels at the acute stage were higher than those at the convalescent stage in ADEM. In seven patients with Gd+ lesions on brain MRI, serum MMP-9 levels and the MMP-9/TIMP-1 ratio at the acute stage were higher than those at the convalescent stage, and serum TIMP1 levels at the acute stage were lower than those at the convalescent stage. In seven patients without Gd+ lesions on brain MRI, serum TIMP-1 levels at the acute stage were higher than those at the convalescent stage. We speculated that MMP-9 is related to lesion formation at the early stage in ADEM and that TIMP-1 is induced to modulate MMP-9 activity. These findings suggest that MMP-9 and TIMP-1 secondarily play some roles in the inflammatory cascade of ADEM.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2005.10.010