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Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children
Background Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL‐10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (...
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| Published in: | Cytometry. Part A 2006-03, Vol.69A (3), p.165-168 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3713-2027dc88600ee2a13e8ccd281bc77e429c873a98afa49e77a12b89619fe5c74e3 |
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| cites | cdi_FETCH-LOGICAL-c3713-2027dc88600ee2a13e8ccd281bc77e429c873a98afa49e77a12b89619fe5c74e3 |
| container_end_page | 168 |
| container_issue | 3 |
| container_start_page | 165 |
| container_title | Cytometry. Part A |
| container_volume | 69A |
| creator | Bocsi, József Richter, Margit Hambsch, Jörg Barten, Markus J. Dähnert, Ingo Schneider, Peter Tárnok, Attila |
| description | Background
Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL‐10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (POEE) in children.
Methods
Th1/Th2 reaction was monitored in children undergoing cardiovascular surgery with (n = 75) and without CPB (n = 29).
Results
Surgery with CPB compared to surgery without CPB induced a transient shift towards Th2. Elevated Th2 response was related to increased vascular permeability and POEE.
Conclusion
The immune suppression/Th2 response is typical for CPB, and at intermediate level is tolerable but at high level could be adverse for the patients. © 2006 International Society for Analytical Cytology |
| doi_str_mv | 10.1002/cyto.a.20213 |
| format | article |
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Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL‐10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (POEE) in children.
Methods
Th1/Th2 reaction was monitored in children undergoing cardiovascular surgery with (n = 75) and without CPB (n = 29).
Results
Surgery with CPB compared to surgery without CPB induced a transient shift towards Th2. Elevated Th2 response was related to increased vascular permeability and POEE.
Conclusion
The immune suppression/Th2 response is typical for CPB, and at intermediate level is tolerable but at high level could be adverse for the patients. © 2006 International Society for Analytical Cytology</description><identifier>ISSN: 1552-4922</identifier><identifier>EISSN: 1552-4930</identifier><identifier>DOI: 10.1002/cyto.a.20213</identifier><identifier>PMID: 16496375</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; anti‐inflammatory ; Cardiopulmonary Bypass ; Child ; Child, Preschool ; Edema - blood ; Edema - immunology ; Flow Cytometry ; Humans ; IgE ; IgG2 ; IL‐10 ; Immunoglobulin E - blood ; Immunoglobulin G - blood ; Interferon-gamma - analysis ; Interleukin-10 - blood ; Interleukin-4 - analysis ; Pericardial Effusion - blood ; Pericardial Effusion - immunology ; Pleural Effusion - blood ; Pleural Effusion - immunology ; postoperative complication ; Postoperative Complications - blood ; Postoperative Complications - immunology ; Th1 Cells - immunology ; Th1 Cells - metabolism ; Th2 Cells - immunology ; Th2 Cells - metabolism ; Th2 shift</subject><ispartof>Cytometry. Part A, 2006-03, Vol.69A (3), p.165-168</ispartof><rights>Copyright © 2006 International Society for Analytical Cytology</rights><rights>(c) 2006 International Society for Analytical Cytology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3713-2027dc88600ee2a13e8ccd281bc77e429c873a98afa49e77a12b89619fe5c74e3</citedby><cites>FETCH-LOGICAL-c3713-2027dc88600ee2a13e8ccd281bc77e429c873a98afa49e77a12b89619fe5c74e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16496375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bocsi, József</creatorcontrib><creatorcontrib>Richter, Margit</creatorcontrib><creatorcontrib>Hambsch, Jörg</creatorcontrib><creatorcontrib>Barten, Markus J.</creatorcontrib><creatorcontrib>Dähnert, Ingo</creatorcontrib><creatorcontrib>Schneider, Peter</creatorcontrib><creatorcontrib>Tárnok, Attila</creatorcontrib><title>Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children</title><title>Cytometry. Part A</title><addtitle>Cytometry A</addtitle><description>Background
Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL‐10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (POEE) in children.
Methods
Th1/Th2 reaction was monitored in children undergoing cardiovascular surgery with (n = 75) and without CPB (n = 29).
Results
Surgery with CPB compared to surgery without CPB induced a transient shift towards Th2. Elevated Th2 response was related to increased vascular permeability and POEE.
Conclusion
The immune suppression/Th2 response is typical for CPB, and at intermediate level is tolerable but at high level could be adverse for the patients. © 2006 International Society for Analytical Cytology</description><subject>Adolescent</subject><subject>anti‐inflammatory</subject><subject>Cardiopulmonary Bypass</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Edema - blood</subject><subject>Edema - immunology</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>IgE</subject><subject>IgG2</subject><subject>IL‐10</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Interferon-gamma - analysis</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-4 - analysis</subject><subject>Pericardial Effusion - blood</subject><subject>Pericardial Effusion - immunology</subject><subject>Pleural Effusion - blood</subject><subject>Pleural Effusion - immunology</subject><subject>postoperative complication</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - immunology</subject><subject>Th1 Cells - immunology</subject><subject>Th1 Cells - metabolism</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><subject>Th2 shift</subject><issn>1552-4922</issn><issn>1552-4930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAQgC0Eorw2ZuSJiRY_kjgZUcVLqsQSBibrYl9UoyQOdgLqvyelFWxMd8OnT3cfIZecLThj4tZsBr-AhWCCywNywtNUzJNCssPfXYgZOY3xnTGZMimOyYxnSZFJlZ6QjzJAFx12Ay3X_LZcC2pdrKCBziB1nXUGBoy093HwPQYY3CdSrOsxOt9FCp2laLEFCvWAgRoI1vl-bFrfQdjQatNDjJOImrVrbMDunBzV0ES82M8z8vpwXy6f5quXx-fl3WpupOJyPv2jrMnzjDFEAVxibowVOa-MUpiIwuRKQpFDDUmBSgEXVV5kvKgxNSpBeUaud94--I8R46BbFw0202fox6gzpVgqUjmBNzvQBB9jwFr3wbXT8ZozvU2st4k16J_EE361945Vi_YP3jedALkDvlyDm39levlWvuy03zMVii0</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Bocsi, József</creator><creator>Richter, Margit</creator><creator>Hambsch, Jörg</creator><creator>Barten, Markus J.</creator><creator>Dähnert, Ingo</creator><creator>Schneider, Peter</creator><creator>Tárnok, Attila</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children</title><author>Bocsi, József ; Richter, Margit ; Hambsch, Jörg ; Barten, Markus J. ; Dähnert, Ingo ; Schneider, Peter ; Tárnok, Attila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3713-2027dc88600ee2a13e8ccd281bc77e429c873a98afa49e77a12b89619fe5c74e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>anti‐inflammatory</topic><topic>Cardiopulmonary Bypass</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Edema - blood</topic><topic>Edema - immunology</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>IgE</topic><topic>IgG2</topic><topic>IL‐10</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Interferon-gamma - analysis</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-4 - analysis</topic><topic>Pericardial Effusion - blood</topic><topic>Pericardial Effusion - immunology</topic><topic>Pleural Effusion - blood</topic><topic>Pleural Effusion - immunology</topic><topic>postoperative complication</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - immunology</topic><topic>Th1 Cells - immunology</topic><topic>Th1 Cells - metabolism</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><topic>Th2 shift</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bocsi, József</creatorcontrib><creatorcontrib>Richter, Margit</creatorcontrib><creatorcontrib>Hambsch, Jörg</creatorcontrib><creatorcontrib>Barten, Markus J.</creatorcontrib><creatorcontrib>Dähnert, Ingo</creatorcontrib><creatorcontrib>Schneider, Peter</creatorcontrib><creatorcontrib>Tárnok, Attila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytometry. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bocsi, József</au><au>Richter, Margit</au><au>Hambsch, Jörg</au><au>Barten, Markus J.</au><au>Dähnert, Ingo</au><au>Schneider, Peter</au><au>Tárnok, Attila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children</atitle><jtitle>Cytometry. Part A</jtitle><addtitle>Cytometry A</addtitle><date>2006-03</date><risdate>2006</risdate><volume>69A</volume><issue>3</issue><spage>165</spage><epage>168</epage><pages>165-168</pages><issn>1552-4922</issn><eissn>1552-4930</eissn><abstract>Background
Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL‐10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (POEE) in children.
Methods
Th1/Th2 reaction was monitored in children undergoing cardiovascular surgery with (n = 75) and without CPB (n = 29).
Results
Surgery with CPB compared to surgery without CPB induced a transient shift towards Th2. Elevated Th2 response was related to increased vascular permeability and POEE.
Conclusion
The immune suppression/Th2 response is typical for CPB, and at intermediate level is tolerable but at high level could be adverse for the patients. © 2006 International Society for Analytical Cytology</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16496375</pmid><doi>10.1002/cyto.a.20213</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cytometry. Part A, 2006-03, Vol.69A (3), p.165-168 |
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| language | eng |
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| source | Wiley |
| subjects | Adolescent anti‐inflammatory Cardiopulmonary Bypass Child Child, Preschool Edema - blood Edema - immunology Flow Cytometry Humans IgE IgG2 IL‐10 Immunoglobulin E - blood Immunoglobulin G - blood Interferon-gamma - analysis Interleukin-10 - blood Interleukin-4 - analysis Pericardial Effusion - blood Pericardial Effusion - immunology Pleural Effusion - blood Pleural Effusion - immunology postoperative complication Postoperative Complications - blood Postoperative Complications - immunology Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism Th2 shift |
| title | Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children |
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