Elevated cytokine levels in children with autism spectrum disorder

This study compared production of IL-2, IFN-γ, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-...

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Bibliographic Details
Published in:Journal of neuroimmunology 2006-03, Vol.172 (1), p.198-205
Main Authors: Molloy, Cynthia A., Morrow, Ardythe L., Meinzen-Derr, Jareen, Schleifer, Kathleen, Dienger, Krista, Manning-Courtney, Patricia, Altaye, Mekibib, Wills-Karp, Marsha
Format: Article
Language:English
Subjects:
Adaptive immune responses
Autism
Autistic Disorder - blood
Case-Control Studies
Child
Child, Preschool
Cytokines
Cytokines - blood
Enzyme-Linked Immunosorbent Assay - methods
Female
Gene Expression Regulation - physiology
Humans
Male
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Summary:This study compared production of IL-2, IFN-γ, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-γ/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-γ/IL-10 than controls. Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2005.11.007