Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys

Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microca...

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Bibliographic Details
Published in:Transplantation proceedings 2005, Vol.37 (1), p.466-469
Main Authors: Elliott, R.B., Escobar, L., Calafiore, R., Basta, G., Garkavenko, O., Vasconcellos, A., Bambra, C.
Format: Article
Language:English
Subjects:
Animals
Capsules
Diabetes Mellitus, Type 1 - surgery
Islets of Langerhans Transplantation - methods
Islets of Langerhans Transplantation - pathology
Islets of Langerhans Transplantation - physiology
Macaca fascicularis
Mice
Mice, Inbred NOD
Swine
Transplantation, Heterologous - pathology
Transplantation, Heterologous - physiology
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Summary:Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. Proof of principle is illustrated for successful xenotransplantation in humans.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.12.198