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Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys
Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microca...
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| Published in: | Transplantation proceedings 2005, Vol.37 (1), p.466-469 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c378t-f0b7bc22c46f6d26c221f85200d27e01c452abc30de4d53505e10246beb3bffa3 |
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| cites | cdi_FETCH-LOGICAL-c378t-f0b7bc22c46f6d26c221f85200d27e01c452abc30de4d53505e10246beb3bffa3 |
| container_end_page | 469 |
| container_issue | 1 |
| container_start_page | 466 |
| container_title | Transplantation proceedings |
| container_volume | 37 |
| creator | Elliott, R.B. Escobar, L. Calafiore, R. Basta, G. Garkavenko, O. Vasconcellos, A. Bambra, C. |
| description | Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. Proof of principle is illustrated for successful xenotransplantation in humans. |
| doi_str_mv | 10.1016/j.transproceed.2004.12.198 |
| format | article |
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The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. 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The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. Proof of principle is illustrated for successful xenotransplantation in humans.</description><subject>Animals</subject><subject>Capsules</subject><subject>Diabetes Mellitus, Type 1 - surgery</subject><subject>Islets of Langerhans Transplantation - methods</subject><subject>Islets of Langerhans Transplantation - pathology</subject><subject>Islets of Langerhans Transplantation - physiology</subject><subject>Macaca fascicularis</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Swine</subject><subject>Transplantation, Heterologous - pathology</subject><subject>Transplantation, Heterologous - physiology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkMlOwzAQhi0EoqXwCijiwC3BS-Kk3BC7VIkD5Ww59hi5ZMN2kPr2uKRCHLl40Xwzo_9D6ILgjGDCrzZZcLLzg-sVgM4oxnlGaEaW1QGak6pkKeWUHaJ5LJCUsLyYoRPvNzj-ac6O0YwUFa54Wc3R6_pnVCO7IIPtu6Q3SWuV69NEdjppZXxCp-Tgx0YG0Mlg3xsIifXx9IntQr_jYaL77gO2_hQdGdl4ONvfC_T2cL--fUpXL4_PtzerVLGyCqnBdVkrSlXODdeUxycxVRHjaFoCJiovqKwVwxpyXbACF0AwzXkNNauNkWyBLqe50cTnCD6I1noFTQwD_egFL0tc5UsWwesJjGG8d2DE4Gwr3VYQLHZKxUb8VSp2SgWhIiqNzef7LWPdxtpv695hBO4mAGLWLwtOeGWjM9DWgQpC9_Y_e74BlNCQXw</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Elliott, R.B.</creator><creator>Escobar, L.</creator><creator>Calafiore, R.</creator><creator>Basta, G.</creator><creator>Garkavenko, O.</creator><creator>Vasconcellos, A.</creator><creator>Bambra, C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys</title><author>Elliott, R.B. ; Escobar, L. ; Calafiore, R. ; Basta, G. ; Garkavenko, O. ; Vasconcellos, A. ; Bambra, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-f0b7bc22c46f6d26c221f85200d27e01c452abc30de4d53505e10246beb3bffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Capsules</topic><topic>Diabetes Mellitus, Type 1 - surgery</topic><topic>Islets of Langerhans Transplantation - methods</topic><topic>Islets of Langerhans Transplantation - pathology</topic><topic>Islets of Langerhans Transplantation - physiology</topic><topic>Macaca fascicularis</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>Swine</topic><topic>Transplantation, Heterologous - pathology</topic><topic>Transplantation, Heterologous - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elliott, R.B.</creatorcontrib><creatorcontrib>Escobar, L.</creatorcontrib><creatorcontrib>Calafiore, R.</creatorcontrib><creatorcontrib>Basta, G.</creatorcontrib><creatorcontrib>Garkavenko, O.</creatorcontrib><creatorcontrib>Vasconcellos, A.</creatorcontrib><creatorcontrib>Bambra, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elliott, R.B.</au><au>Escobar, L.</au><au>Calafiore, R.</au><au>Basta, G.</au><au>Garkavenko, O.</au><au>Vasconcellos, A.</au><au>Bambra, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2005</date><risdate>2005</risdate><volume>37</volume><issue>1</issue><spage>466</spage><epage>469</epage><pages>466-469</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. 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| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 2005, Vol.37 (1), p.466-469 |
| issn | 0041-1345 1873-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67708493 |
| source | ScienceDirect Journals |
| subjects | Animals Capsules Diabetes Mellitus, Type 1 - surgery Islets of Langerhans Transplantation - methods Islets of Langerhans Transplantation - pathology Islets of Langerhans Transplantation - physiology Macaca fascicularis Mice Mice, Inbred NOD Swine Transplantation, Heterologous - pathology Transplantation, Heterologous - physiology |
| title | Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys |
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