Loading…

Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1)

By using the C-terminal 112-residue of band 3 to screen the K562 cDNA library, we find that the p16 interacts with band 3, which was confirmed both in yeast and in mammalian cells. Functional experiments show that p16 facilitates the movement of band 3 to plasma membrane with increased anion transpo...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 2005-04, Vol.579 (10), p.2105-2110
Main Authors: Fu, Guo-Hui, Wang, Yong, Xi, Yu-Hui, Shen, Wei-Wei, Pan, Xiao-Yan, Shen, Wu-Zhong, Jiang, Xiao-Shu, Chen, Guo-Qiang
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:By using the C-terminal 112-residue of band 3 to screen the K562 cDNA library, we find that the p16 interacts with band 3, which was confirmed both in yeast and in mammalian cells. Functional experiments show that p16 facilitates the movement of band 3 to plasma membrane with increased anion transport activity in 293t cells. Moreover, expression of endogenous p16 in 293t cells was increased at 24 and 36 h after transfection with band 3. Our findings provide a novel regulation pathway for both band 3 and p16.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2005.02.063