Functional role of AMP-activated protein kinase in the heart during exercise

AMP-activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and...

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Bibliographic Details
Published in:FEBS letters 2005-04, Vol.579 (10), p.2045-2050
Main Authors: Musi, Nicolas, Hirshman, Michael F., Arad, Michael, Xing, Yanqiu, Fujii, Nobuharu, Pomerleau, Jason, Ahmad, Ferhaan, Berul, Charles I., Seidman, Jon G., Tian, Rong, Goodyear, Laurie J.
Format: Article
Language:English
Subjects:
Acetyl CoA carboxylase
AMP-activated protein kinase
AMP-Activated Protein Kinases
Animals
Echocardiography
Exercise
Heart
Heart - physiology
Mice
Mice, Transgenic
Multienzyme Complexes - metabolism
Myocardium - enzymology
p38
p38 Mitogen-Activated Protein Kinases - metabolism
Phosphorylation
Physical Conditioning, Animal
Protein-Serine-Threonine Kinases - metabolism
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Summary:AMP-activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac-specific dominant-negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2005.02.052