Developmental consequences of antenatal dexamethasone treatment in nonhuman primates

Research assessing fetal exposure to dexamethasone and betamethasone in animals has raised concerns about the potential for adverse side effects following antenatal treatments, not withstanding the beneficial and desired improvement in lung function. Some of the inhibitory effects on physical growth...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2005-04, Vol.29 (2), p.227-235
Main Authors: Coe, Christopher L., Lubach, Gabriele R.
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Betamethasone
Biological and medical sciences
Brain - drug effects
Brain - growth & development
Cortisol
Dexamethasone
Dexamethasone - pharmacology
Digestive System - drug effects
Digestive System - growth & development
Endocrine System - drug effects
Endocrine System - growth & development
Female
Fetal
Fetal Development - drug effects
Fetal Development - physiology
Fundamental and applied biological sciences. Psychology
Glucocorticoids - pharmacology
Hippocampus
Humans
Immune
Immune System - drug effects
Immune System - growth & development
Lung - drug effects
Lung - growth & development
Mammalian reproduction. General aspects
Miscellaneous
Monkey
Placenta
Pregnancy
Prematurity
Prenatal Exposure Delayed Effects
Primates
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Vertebrates: reproduction
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Summary:Research assessing fetal exposure to dexamethasone and betamethasone in animals has raised concerns about the potential for adverse side effects following antenatal treatments, not withstanding the beneficial and desired improvement in lung function. Some of the inhibitory effects on physical growth and the long-term alterations in endocrine, immune and neural physiology may reflect species differences in the fetal sensitivity of rodents and monkeys to corticosteroids or perhaps could be attributed to the higher drug doses often used in animal studies. However, since steroidal drugs can be administered for extended periods in clinical practice, and also are occasionally given in the range found to cause significant effects on the brain and immune responses of infant monkeys, the simian studies have important cautionary implications for obstetrical and pediatric practice.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2004.10.003