Comparison of DXA, QCT and trabecular structure in β-thalassaemia

:  Osteopathy, as a major feature of homozygous β‐thalassaemia, is a multifactorial disorder, not fully understood. We studied the lumbar vertebrae of 48 patients using Dual‐Energy X‐ray Absorptiometry (DXA) and Quantitative Computed Tomography (QCT), and we focused on structural properties, assesse...

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Published in:European journal of haematology 2005-05, Vol.74 (5), p.430-437
Main Authors: Mylona, Maria, Leotsinides, Michalis, Alexandrides, Theodoros, Zoumbos, Nikolaos, Dimopoulos, Panagiotis A.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adolescent
Adult
beta-Thalassemia - complications
beta-Thalassemia - diagnostic imaging
Bone Demineralization, Pathologic
Bone Density
dual-energy X-ray absorptiometry
Female
homozygous β-thalassaemia
Humans
Hypogonadism - diagnostic imaging
Hypogonadism - etiology
Hypoparathyroidism - diagnostic imaging
Hypoparathyroidism - etiology
Male
Middle Aged
osteoporosis
Osteoporosis - diagnostic imaging
Osteoporosis - epidemiology
quantitative computed tomography
Spine - diagnostic imaging
Tomography, X-Ray Computed
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Summary::  Osteopathy, as a major feature of homozygous β‐thalassaemia, is a multifactorial disorder, not fully understood. We studied the lumbar vertebrae of 48 patients using Dual‐Energy X‐ray Absorptiometry (DXA) and Quantitative Computed Tomography (QCT), and we focused on structural properties, assessed by High Resolution Computed Tomography (HRCT). Bone Mineral Density (BMD) values were expressed as Z‐scores and the results were correlated. The effect of age, sex, and type of thalassaemia and hormonal factors on BMD was assessed. We estimated, with HRCT, the cortex integrity and the number and thickness of trabeculae; the latter were classified to a three‐grade scale. Our results showed the overall prevalence of osteoporosis to be 44% with DXA and 6% with QCT. Both techniques revealed an inverse correlation between age and BMD, whereas hormonal factors demonstrated associations with QCT and DXA measurements. The correlation coefficient between DXA's BMD and QCT's trabecular BMD was 0.545 (P 
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2005.00411.x