Error-prone DNA repair and translesion synthesis: Focus on the replication fork

Dean Rupp and Paul Howard-Flanders showed that, following exposure to ultraviolet light, bacteria deficient in nucleotide excision repair synthesised DNA with minimal delay and in pieces roughly the size of the distances between pyrimidine dimmers. The discontinuities or gaps between these pieces we...

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Bibliographic Details
Published in:DNA repair 2005-05, Vol.4 (5), p.618-634
Main Author: Bridges, Bryn A.
Format: Article
Language:English
Subjects:
Bacteriology
Bacteriophage lambda - genetics
Bacteriophage lambda - radiation effects
Biological and medical sciences
DNA - isolation & purification
DNA - metabolism
DNA - radiation effects
DNA Damage
DNA Repair
DNA Replication
DNA synthesis
Escherichia coli - genetics
Escherichia coli - radiation effects
Fundamental and applied biological sciences. Psychology
Growth, nutrition, cell differenciation
Microbiology
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Pyrimidine Dimers - analysis
Replication fork
SOS Response (Genetics)
Translesion synthesis
Ultraviolet Rays
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Summary:Dean Rupp and Paul Howard-Flanders showed that, following exposure to ultraviolet light, bacteria deficient in nucleotide excision repair synthesised DNA with minimal delay and in pieces roughly the size of the distances between pyrimidine dimmers. The discontinuities or gaps between these pieces were subsequently sealed. This led directly to the hypothesis of translesion synthesis.
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2004.11.005