Characteristic tissue interaction of the diastema region in mice

Rodents have a toothless diastema between the incisor and the first molar, which may contain rudimentary tooth germs. In the lower diastema region of mice at E13, the rudimentary tooth germs, which developed into the bud stage before its removal by apoptosis, was found. The immunoreactivity to tenas...

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Bibliographic Details
Published in:Archives of oral biology 2005-02, Vol.50 (2), p.189-198
Main Authors: Yamamoto a,b,c, Hitoshi, Cho a, Sung-Won, Song a, Soo-Jin, Hwang a, Heui-Jung, Lee a, Min-Jung, Kim a, Jae-Young, Jung a,b, Han-Sung
Format: Article
Language:English
Subjects:
Animals
Condensation
Dentistry
Diastema
Diastema - embryology
DNA-Binding Proteins - genetics
Epithelial–mesenchymal interaction
Eutherian dental formula
Gene expression
Homeodomain Proteins - genetics
Immunohistochemistry - methods
In Situ Hybridization - methods
Incisor
Mesoderm - physiology
Mice
Mice, Inbred ICR
Molar
MSX1 Transcription Factor
Odontogenesis - physiology
Recombination
Tenascin
Tissue Culture Techniques
Tooth Germ - physiology
Transcription Factors - genetics
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Summary:Rodents have a toothless diastema between the incisor and the first molar, which may contain rudimentary tooth germs. In the lower diastema region of mice at E13, the rudimentary tooth germs, which developed into the bud stage before its removal by apoptosis, was found. The immunoreactivity to tenascin was observed in the condensed mesenchyme around the normal tooth bud and was detected in only the basement membrane in the diastema bud. This result shows that the relationship between mesenchymal condensation and tooth development. The similar patterns of Msx-1 and Msx-2 expression between the tooth bud and the diastema bud show that the diastema bud may have some other genetic mechanism in the developmental arrest of the rudimentary tooth germs rather than the Msx-1 and Msx-2 expression. Strikingly, the induction of the tooth formation was possible using tissue recombination between the oral epithelium of the diastema bud and the dental mesenchyme of the molar tooth bud, which indicates the potential capability of the diastema in the tooth formation. In conclusion, it is suggested that the condensed mesenchyme may be the key to tooth development.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2004.11.010