Role of Tissue Kallikrein–Kininogen–Kinin Pathways in the Cardiovascular System

All the components of the kallikrein–kinin system are located in the cardiac muscle, and its deficiency may lead to cardiac dysfunction. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischemia, myocardial infarction a...

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Bibliographic Details
Published in:Archives of medical research 2006-04, Vol.37 (3), p.299-306
Main Author: Sharma, Jagdish N.
Format: Article
Language:English
Subjects:
Angiotensin-converting enzyme inhibitors
Animals
Cardiac diseases
Cardioprotection
Cardiovascular System - metabolism
Heart Diseases - metabolism
Humans
Hypertension
Kallikrein–kinin system
Kininogens - metabolism
Kinins - metabolism
Models, Biological
Tissue Kallikreins - metabolism
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Summary:All the components of the kallikrein–kinin system are located in the cardiac muscle, and its deficiency may lead to cardiac dysfunction. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischemia, myocardial infarction and left ventricular hypertrophy have suggested that the reduced activity of the local kallikrein–kinin system may be instrumental for the induction of cardiovascular-related diseases. The cardioprotective property of the angiotensin converting enzyme inhibitors is primarily mediated via kinin-releasing pathway, which may cause regression of the left ventricular hypertrophy in hypertensive situations. The ability of kallikrein gene delivery to produce a wide spectrum of beneficial effects makes it an excellent candidate in treating hypertension, cardiovascular and renal diseases. In addition, stable kinin agonists may also be available in the future as therapeutic agents for cardiovascular and renal disorders.
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2005.08.001