Increased Melanin Concentrating Hormone Receptor Type I in the Human Hypothalamic Infundibular Nucleus in Cachexia

Melanin-concentrating hormone (MCH) exerts a positive regulation on appetite and binds to the G protein-coupled receptors, MCH1R and MCH2R. In rodents, MCH is produced by neurons in the lateral hypothalamus with projections to various hypothalamic and other brain sites. In the present study, MCH1R w...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2005-04, Vol.90 (4), p.2412-2419
Main Authors: Unmehopa, Unga A., van Heerikhuize, Joop J., Spijkstra, Wenda, Woods, John W., Howard, Andrew D., Zycband, Emanuel, Feighner, Scott D., Hreniuk, Donna L., Palyha, Oksana C., Guan, Xiao-Ming, MacNeil, Douglas J., Van der Ploeg, Lex H. T., Swaab, Dick F.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Animals
Arcuate Nucleus of Hypothalamus - chemistry
Biological and medical sciences
Cachexia - metabolism
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypothalamus - chemistry
Immunohistochemistry
Male
Medical sciences
Middle Aged
Rabbits
Rats
Receptors, Somatostatin - analysis
Vertebrates: endocrinology
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Summary:Melanin-concentrating hormone (MCH) exerts a positive regulation on appetite and binds to the G protein-coupled receptors, MCH1R and MCH2R. In rodents, MCH is produced by neurons in the lateral hypothalamus with projections to various hypothalamic and other brain sites. In the present study, MCH1R was shown, by immunocytochemistry, to be present in the human infundibular nucleus/median eminence, paraventricular nucleus, lateral hypothalamic area, and perifornical area, although in the latter two regions, only a few MCH1R-containing cells were found. In addition, MCH1R staining was found in nerve fibers in the periventricular nucleus, dorsomedial and ventromedial nucleus, suprachiasmatic nucleus, and tuberomammillary nucleus. A significant 1.6 times increase in the number of MCH1R cell body staining was found in the infundibular nucleus in postmortem brain material of cachectic patients, compared with matched controls, supporting a role for this receptor in energy homeostasis in the human.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2004-1145