Malignant Fibrous Histiocytoma of the Breast. Report of Two Cases and Review of the Literature

Sarcomas of the breast are uncommon, accounting for less than 1% of all primary malignancies. Among these tumors, malignant fibrous histiocytoma (MFH) is very rare. Two cases of this neoplasm are reported, with histological findings and surgical treatment. The issue of radiation-induced lesions afte...

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Bibliographic Details
Published in:Anticancer research 2005-01, Vol.25 (1B), p.505-508
Main Authors: DE CESARE, Alessandro, FIORI, Enrico, BURZA, Antonio, CIARDI, Antonio, BONONI, Marco, IZZO, Luciano, VOLPINO, Patrizia, CAVALLARO, Antonino, CANGEMI, Vincenzo
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast - pathology
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Female
Fibroblasts - metabolism
Histiocytoma, Benign Fibrous - diagnosis
Histiocytoma, Benign Fibrous - pathology
Humans
Immunohistochemistry
Lymphatic Metastasis
Mammography
Medical sciences
Time Factors
Tumors
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Summary:Sarcomas of the breast are uncommon, accounting for less than 1% of all primary malignancies. Among these tumors, malignant fibrous histiocytoma (MFH) is very rare. Two cases of this neoplasm are reported, with histological findings and surgical treatment. The issue of radiation-induced lesions after surgery for carcinoma and the necessity for a correct preoperative diagnosis is examined. A review of the available literature evaluates the histopathological and biological features of MFH of the breast, for which there are no prospective trials, owing to the rarity of this kind of neoplasm. The extent of surgery or role of axillary lymph nodes dissection and multimodality therapy are discussed.
ISSN:0250-7005
1791-7530