Parathyroid Hormone-related Protein-Secreting Uterine Endometrioid Adenocarcinoma

The diagnosis of parathyroid hormone-related protein (PTHrP)-secreting metastatic uterine endometrioid cancer was made in a 32-year-old Japanese woman with humoral hypercalcemia of malignancy. The primary endometrial cancer had been removed, and the tumor was diagnosed as Grade 1 endometrioid adenoc...

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Bibliographic Details
Published in:Japanese journal of clinical oncology 2006-02, Vol.36 (2), p.113-115
Main Authors: Kinugasa, Yukio, Morishige, Ken-ichiro, Kamiura, Shoji, Tsukamoto, Yoshitane, Saji, Fumitaka
Format: Article
Language:English
Subjects:
Adult
Carcinoma, Endometrioid - chemistry
Carcinoma, Endometrioid - metabolism
Carcinoma, Endometrioid - pathology
endometrial cancer
Endometrial Neoplasms - chemistry
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
endometrioid adenocarcinoma
Fatal Outcome
Female
Humans
humoral hypercalcemia of malignancy
Hypercalcemia - diagnosis
Hypercalcemia - etiology
Immunohistochemistry
Japan
parathyroid hormone-related protein
Parathyroid Hormone-Related Protein - analysis
Parathyroid Hormone-Related Protein - blood
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Summary:The diagnosis of parathyroid hormone-related protein (PTHrP)-secreting metastatic uterine endometrioid cancer was made in a 32-year-old Japanese woman with humoral hypercalcemia of malignancy. The primary endometrial cancer had been removed, and the tumor was diagnosed as Grade 1 endometrioid adenocarcinoma with shallow myometrial invasion. Salvage chemotherapy (paclitaxel and calboplatin) was started from 5 months after surgery when recurrent tumors were detected in the peritoneum and liver. Despite the salvage chemotherapy, the tumor progressed and hypercalcemia became evident with elevated PTHrP whereas no bone metastasis was identified. To the best of our knowledge, this is the first reported case of hypercalcemia due to PTHrP secretion in uterine endometrioid adenocarcinoma.
ISSN:0368-2811
1465-3621
DOI:10.1093/jjco/hyi215