Characterization of mast cell subpopulations in lip cancer

Background:  Lip squamous cell carcinoma (SCC) is the most common form of oral cancer. Human mast cells (MCs), which are increased in lip SCC, are classified by their protease content in tryptase‐positive (MCT) and tryptase/chymase‐positive (MCTC). MC proteases are associated with tumor progression...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2005-05, Vol.34 (5), p.268-273
Main Authors: Rojas, I. G., Spencer, M. L., Martínez, A., Maurelia, M. A., Rudolph, M. I.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - pathology
Cell Degranulation
chymase
Chymases
Dentistry
Extracellular Matrix - metabolism
Female
Humans
Immunoenzyme Techniques
lip cancer
Lip Neoplasms - enzymology
Lip Neoplasms - pathology
Male
mast cells
Mast Cells - enzymology
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
proteases
Serine Endopeptidases - analysis
Serine Endopeptidases - metabolism
Statistics, Nonparametric
tryptase
Tryptases
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Summary:Background:  Lip squamous cell carcinoma (SCC) is the most common form of oral cancer. Human mast cells (MCs), which are increased in lip SCC, are classified by their protease content in tryptase‐positive (MCT) and tryptase/chymase‐positive (MCTC). MC proteases are associated with tumor progression and angiogenesis. The aim of this study was to quantify and characterize MC subpopulations in lip SCC. Methods:  Serial sections from lip SCC (n = 21) and normal lip vermilion (n = 8) biopsies were stained immunohistochemically for tryptase and enzymehistochemically for chymase to determine MC subpopulation density and distribution. Results:  MCT and MCTC were increased in lip SCC when compared with normal lip (P 
ISSN:0904-2512
1600-0714
DOI:10.1111/j.1600-0714.2004.00297.x