Evaluation of Serum Levels of Interleukin (IL)–6, IL-10, and Tumor Necrosis Factor–α in Patients with Crimean-Congo Hemorrhagic Fever

• Published in: The Journal of infectious diseases 2006-04, Vol.193 (7), p.941-944
• Main Authors: Ergonul, Onder, Tuncbilek, Semra, Baykam, Nurcan, Celikbas, Aysel, Dokuzoguz, Basak
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Coagulation; Crimean Congo hemorrhagic fever virus; Cytokines; Disseminated Intravascular Coagulation; Ebola virus; Female; Fundamental and applied biological sciences. Psychology; Hemorrhagic Fever, Crimean - immunology; Hemorrhagic Fever, Crimean - mortality; Humans; Infections; Infectious diseases; Interleukin-10 - blood; Interleukin-6 - blood; Interleukins; Male; Medical sciences; Microbiology; Middle Aged; Mortality; Platelets; Statistics as Topic; Tumor Necrosis Factor-alpha - analysis; Viruses
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/500836

We investigated the role played by cytokines in the mortality of patients with Crimean-Congo hemorrhagic fever (CCHF). Serum levels of several cytokines were measured in 3 patients with fatal CCHF and in 27 patients with nonfatal CCHF. Levels of interleukin (IL)–6 (P⩽.001) and tumor necrosis factor (TNF)–α (P=.004) were significantly higher in patients with fatal CCHF than in patients with nonfatal CCHF, whereas levels of IL-10 were not significantly different between the 2 groups (P=.937). Disseminated intravascular coagulation (DIC) scores were also higher in the patients with fatal CCHF (P=.023). Levels of IL-6 and TNF-α were positively correlated with DIC scores, whereas levels of IL-10 were negatively correlated with DIC scores. In conclusion, these findings demonstrate that proinflammatory cytokines play a major role in the mortality of patients with CCHF