Cutting Edge: The Direct Action of Type I IFN on CD4 T Cells Is Critical for Sustaining Clonal Expansion in Response to a Viral but Not a Bacterial Infection

The action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear. To address this, we transferred IFN-I receptor-deficient (IFN-IR(0)) and -sufficient (wild-type, WT) TCR-transgenic CD4 T cells into WT mice and analyzed their response to immunization. In re...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2006-03, Vol.176 (6), p.3315-3319
Main Authors: Havenar-Daughton, Colin, Kolumam, Ganesh A, Murali-Krishna, Kaja
Format: Article
Language:English
Subjects:
Animals
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cell Proliferation
Cells, Cultured
Clone Cells - cytology
Clone Cells - immunology
Clone Cells - metabolism
Female
Immunization
Interferon Type I - immunology
Interferon Type I - metabolism
Lymphocytic choriomeningitis virus - immunology
Male
Membrane Proteins - deficiency
Membrane Proteins - genetics
Membrane Proteins - immunology
Mice
Phenotype
Receptor, Interferon alpha-beta
Receptors, Interferon - deficiency
Receptors, Interferon - genetics
Receptors, Interferon - immunology
Signal Transduction - immunology
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Summary:The action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear. To address this, we transferred IFN-I receptor-deficient (IFN-IR(0)) and -sufficient (wild-type, WT) TCR-transgenic CD4 T cells into WT mice and analyzed their response to immunization. In response to lymphocytic choriomeningitis virus immunization, WT CD4 T cells expanded approximately 100-fold, whereas IFN-IR(0) CD4 T cells expanded
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.176.6.3315