Effects of fluoxetine on cellular immune response in stressed mice

We studied the effects of fluoxetine, a non-tricyclic antidepressant drug that selectively inhibits re-uptake of serotonin by presinaptic neurons in the brain, on cellular immune responses in mice exposed to a chronic auditory stressor. The natural killer (NK) cell activity was reduced after 4, 8, 1...

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Bibliographic Details
Published in:Neuroscience letters 2006-04, Vol.396 (3), p.247-251
Main Authors: Núñez, María J., Balboa, José, Rodrigo, Elena, Brenlla, Julio, González-Peteiro, Mercedes, Freire-Garabal, Manuel
Format: Article
Language:English
Subjects:
Acoustic Stimulation - adverse effects
Analysis of Variance
Animals
Antidepressive Agents, Second-Generation - pharmacology
Biological and medical sciences
Cell Count - methods
Cells, Cultured
Cytotoxic T-lymphocytes (CTL)
Disease Models, Animal
Dose-Response Relationship, Drug
Fluoxetine
Fluoxetine - pharmacology
Fundamental and applied biological sciences. Psychology
Immunity
Immunity, Cellular - drug effects
Killer Cells, Natural - drug effects
Male
Mice
Mice, Inbred BALB C
Mitomycin - pharmacology
Natural killer (NK) cell activity
Spleen - pathology
Stress
Stress, Physiological - etiology
Stress, Physiological - immunology
T-Lymphocytes, Cytotoxic - metabolism
Time Factors
Vertebrates: nervous system and sense organs
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Summary:We studied the effects of fluoxetine, a non-tricyclic antidepressant drug that selectively inhibits re-uptake of serotonin by presinaptic neurons in the brain, on cellular immune responses in mice exposed to a chronic auditory stressor. The natural killer (NK) cell activity was reduced after 4, 8, 12, 16 and 20 days of stress exposure with a partial recovery on days 16 and 20. Daily treatment with fluoxetine partially reversed these adverse effects of stress in a dose-dependent manner. Significant differences appeared when fluoxetine was administered at 2 mg/kg and maximum effect was reached at doses of 5 mg/kg. The capacity of T cells to generate cytotoxic T-lymphocytes (CTL) in mixed lymphocyte cultures and in vivo was reduced after 4 days of stress application and this effect was partially reduced when mice were injected with 5 mg/kg of fluoxetine. Nevertheless, in our experiments, fluoxetine did not significantly affect the cellular immunity in unstressed mice. In conclusion, fluoxetine seems to partially recover the adverse effects of chronic stress on cellular immune response
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.11.042