Macroscopic 2D Networks Self-Assembled from Nanometer-Sized Protein/DNA Complexes

We demonstrate the self-assembly of DNA and DNA binding proteins into two-dimensional networks that are then addressable by sending a second protein to a specific recognition site on the DNA network. These networks cover centimeters in area but can be addressed with nanometer precision. This hierarc...

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Bibliographic Details
Published in:Nano letters 2006-03, Vol.6 (3), p.365-370
Main Authors: Manzanera, Maximino, Frankel, Daniel J, Li, Haitao, Zhou, Dejian, Bruckbauer, Andreas, Kreutzmann, Peter, Blackburn, Jonathan M, Abell, Chris, Rayment, Trevor, Klenerman, David, Barker, Paul D
Format: Article
Language:English
Subjects:
Base Sequence
Cross-disciplinary physics: materials science
rheology
DNA - chemistry
DNA - metabolism
DNA - ultrastructure
Exact sciences and technology
Materials science
Methods of nanofabrication
Microscopy, Atomic Force
Models, Molecular
Nanostructures - chemistry
NF-kappa B - chemistry
NF-kappa B - metabolism
NF-kappa B - ultrastructure
Nucleic Acid Conformation
Physics
Protein Binding
Protein Structure, Quaternary
Proteins - chemistry
Proteins - metabolism
Proteins - ultrastructure
Self-assembly
Spectrum Analysis
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Summary:We demonstrate the self-assembly of DNA and DNA binding proteins into two-dimensional networks that are then addressable by sending a second protein to a specific recognition site on the DNA network. These networks cover centimeters in area but can be addressed with nanometer precision. This hierarchical self-assembly of specific DNA protein complexes will be the basis for complex positioning of single molecules in two and three dimensions.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl051599+