Shaping Amorphous Calcium Carbonate Films into 2D Model Substrates for Bone Cell Culture

Boning up on patterning: Patterned calcium carbonate films with dimensions of 200–400 μm were obtained using the photolithographic properties of a polysilane‐based ABA block copolymer, PHEMA‐PMPS‐PHEMA. These patterns may serve as a 2D model system for CaCO3 biomaterials in which both the CaCO3 reso...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-03, Vol.45 (11), p.1762-1767
Main Authors: Popescu, Daniela C., van Leeuwen, Ellen N. M., Rossi, Nicholas A. A., Holder, Simon J., Jansen, John A., Sommerdijk, Nico A. J. M.
Format: Article
Language:English
Subjects:
Alkaline Phosphatase
Animals
biomimetic synthesis
block copolymers
bone cells
Bone Marrow Cells - physiology
Bone Marrow Cells - ultrastructure
Calcification, Physiologic
Calcium Carbonate - chemistry
Cell Differentiation
Cell Proliferation
Cells, Cultured
Coated Materials, Biocompatible
Materials Testing
Models, Biological
Osteogenesis
photolithography
Rats
Silicon - chemistry
Stromal Cells - physiology
Stromal Cells - ultrastructure
thin films
Tissue Engineering
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Summary:Boning up on patterning: Patterned calcium carbonate films with dimensions of 200–400 μm were obtained using the photolithographic properties of a polysilane‐based ABA block copolymer, PHEMA‐PMPS‐PHEMA. These patterns may serve as a 2D model system for CaCO3 biomaterials in which both the CaCO3 resorption by osteoclasts and the calcium phosphate deposition by osteoblasts can be monitored using optical microscopy.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502602