Paraneoplastic progressive supranuclear palsy syndrome in a patient with B-cell lymphoma

An important component in the diagnosis of atypical parkinsonian disorders is the exclusion of secondary causes. Paraneoplastic causes of parkinsonism are extremely rare. We describe a case which presented initially as probable progressive supranuclear palsy (PSP) but on follow-up displayed a rapidl...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2005-05, Vol.11 (3), p.187-191
Main Authors: Tan, J.H., Goh, B.C., Tambyah, P.A., Wilder-Smith, E.
Format: Article
Language:English
Subjects:
Aged
Humans
Lymphoma
Lymphoma, B-Cell - complications
Magnetic Resonance Imaging
Male
Paraneoplastic
Paraneoplastic Polyneuropathy - diagnosis
Paraneoplastic Polyneuropathy - etiology
Progressive supranuclear palsy
Supranuclear Palsy, Progressive - diagnosis
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Summary:An important component in the diagnosis of atypical parkinsonian disorders is the exclusion of secondary causes. Paraneoplastic causes of parkinsonism are extremely rare. We describe a case which presented initially as probable progressive supranuclear palsy (PSP) but on follow-up displayed a rapidly progressive course, unexplained fever, peripheral neuropathy and an abnormal CSF. We highlight the difficulties faced in formulating a diagnosis for this unusual case prior to the discovery of an occult B-cell lymphoma, and discuss its relevance in the exclusion criteria for PSP. A paraneoplastic cause should be considered if disease progression is unusually rapid.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2004.09.003