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Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines
Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed, along with its receptors, in organs and body tissues. ANP is well known to inhibit aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone production is controversial. In vivo experiments showe...
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| Published in: | International journal of molecular medicine 2006-04, Vol.17 (4), p.633-636 |
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| Main Authors: | , , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 636 |
| container_issue | 4 |
| container_start_page | 633 |
| container_title | International journal of molecular medicine |
| container_volume | 17 |
| creator | Raha, Dipali Tortorella, Cinzia Neri, Giuliano Prasad, Anita Raza, Bushra Raskar, Ranu Dubey, Rakhi Sen, Nisarga Macchi, Carlo Malendowicz, Ludwick Ahmad, M Nussdorfer, Gastone |
| description | Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed,
along with its receptors, in organs and body tissues. ANP is well known to inhibit
aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone
production is controversial. In vivo experiments showed that prolonged ANP administration
raised the plasma concentration of cortisol in both normal and dexamethasone/captopril-treated
guinea pigs (i.e. in animals with pharmacologically interrupted hypothalamic-pituitary-adrenal
axis and renin-angiotensin system). ANP did not affect cortisol secretion from
dispersed guinea pig zona fasciculata-reticularis cells, but enhanced catecholamine
release from adrenomedullary cells. ANP stimulated cortisol output from guinea
pig adrenal slices containing medullary chromaffin tissue, and the β-adrenoceptor
antagonist l-alprenolol blocked this effect. The conclusion is drawn that ANP,
when the structural integrity of the adrenal gland is preserved, is able to enhance
glucocorticoid secretion in guinea pigs, through an indirect mechanism involving
the rise in the catecholamine release, which in turn, acting in a paracrine manner,
stimulate secretion of inner adrenocortical cells. |
| doi_str_mv | 10.3892/ijmm.17.4.633 |
| format | article |
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along with its receptors, in organs and body tissues. ANP is well known to inhibit
aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone
production is controversial. In vivo experiments showed that prolonged ANP administration
raised the plasma concentration of cortisol in both normal and dexamethasone/captopril-treated
guinea pigs (i.e. in animals with pharmacologically interrupted hypothalamic-pituitary-adrenal
axis and renin-angiotensin system). ANP did not affect cortisol secretion from
dispersed guinea pig zona fasciculata-reticularis cells, but enhanced catecholamine
release from adrenomedullary cells. ANP stimulated cortisol output from guinea
pig adrenal slices containing medullary chromaffin tissue, and the β-adrenoceptor
antagonist l-alprenolol blocked this effect. The conclusion is drawn that ANP,
when the structural integrity of the adrenal gland is preserved, is able to enhance
glucocorticoid secretion in guinea pigs, through an indirect mechanism involving
the rise in the catecholamine release, which in turn, acting in a paracrine manner,
stimulate secretion of inner adrenocortical cells.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.17.4.633</identifier><identifier>PMID: 16525720</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject><![CDATA[Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adrenal Medulla - drug effects ; Adrenal Medulla - metabolism ; Alprenolol - administration & dosage ; Alprenolol - pharmacology ; Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Atrial Natriuretic Factor - administration & dosage ; Atrial Natriuretic Factor - pharmacology ; Captopril - administration & dosage ; Captopril - pharmacology ; Catecholamines - secretion ; Dexamethasone - administration & dosage ; Dexamethasone - pharmacology ; Dose-Response Relationship, Drug ; Epinephrine - secretion ; Female ; Glucocorticoids - administration & dosage ; Glucocorticoids - pharmacology ; Guinea Pigs ; Hydrocortisone - blood ; Hydrocortisone - secretion ; In Vitro Techniques ; Injections, Subcutaneous ; Male ; Norepinephrine - secretion ; Paracrine Communication - drug effects ; Paracrine Communication - physiology]]></subject><ispartof>International journal of molecular medicine, 2006-04, Vol.17 (4), p.633-636</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16525720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raha, Dipali</creatorcontrib><creatorcontrib>Tortorella, Cinzia</creatorcontrib><creatorcontrib>Neri, Giuliano</creatorcontrib><creatorcontrib>Prasad, Anita</creatorcontrib><creatorcontrib>Raza, Bushra</creatorcontrib><creatorcontrib>Raskar, Ranu</creatorcontrib><creatorcontrib>Dubey, Rakhi</creatorcontrib><creatorcontrib>Sen, Nisarga</creatorcontrib><creatorcontrib>Macchi, Carlo</creatorcontrib><creatorcontrib>Malendowicz, Ludwick</creatorcontrib><creatorcontrib>Ahmad, M</creatorcontrib><creatorcontrib>Nussdorfer, Gastone</creatorcontrib><title>Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed,
along with its receptors, in organs and body tissues. ANP is well known to inhibit
aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone
production is controversial. In vivo experiments showed that prolonged ANP administration
raised the plasma concentration of cortisol in both normal and dexamethasone/captopril-treated
guinea pigs (i.e. in animals with pharmacologically interrupted hypothalamic-pituitary-adrenal
axis and renin-angiotensin system). ANP did not affect cortisol secretion from
dispersed guinea pig zona fasciculata-reticularis cells, but enhanced catecholamine
release from adrenomedullary cells. ANP stimulated cortisol output from guinea
pig adrenal slices containing medullary chromaffin tissue, and the β-adrenoceptor
antagonist l-alprenolol blocked this effect. The conclusion is drawn that ANP,
when the structural integrity of the adrenal gland is preserved, is able to enhance
glucocorticoid secretion in guinea pigs, through an indirect mechanism involving
the rise in the catecholamine release, which in turn, acting in a paracrine manner,
stimulate secretion of inner adrenocortical cells.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenal Medulla - drug effects</subject><subject>Adrenal Medulla - metabolism</subject><subject>Alprenolol - administration & dosage</subject><subject>Alprenolol - pharmacology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - administration & dosage</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Captopril - administration & dosage</subject><subject>Captopril - pharmacology</subject><subject>Catecholamines - secretion</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epinephrine - secretion</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - pharmacology</subject><subject>Guinea Pigs</subject><subject>Hydrocortisone - blood</subject><subject>Hydrocortisone - secretion</subject><subject>In Vitro Techniques</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Norepinephrine - secretion</subject><subject>Paracrine Communication - drug effects</subject><subject>Paracrine Communication - physiology</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpFkU1r3DAQhk1padK0x16LTr0Ub60PW1JvIaQfEOilhd7MWB5vFGTJleyF_L7-scyyW4IOo8PzPoz0VtV73uykseKzf5jnHdc7teukfFFdcm15LZT685LuvNG11G13Ub0p5aFpRKuseV1d8K4VrRbNZfXves0eAotAc8u4escWXFY_IsN4D9FhYS7l1ZcUWEF3RFJkU04z228-ItSL3zMYM0by7APE8Qu7PZCAsmxKmUFkPo4-o1vZAhlcphib0ZHel5ktOQ0whEeiDikcfNyz9R5ZSI6EGQNCQZYmSoxbCJAfmYOV0inATKbytno1QSj47jyvqt9fb3_dfK_vfn77cXN9VzspxFo7J00zTdJaPZpBGTPaDmTDB92Zlg_CIlrBQbtBKt4YLpw1oCalW2itkIO8qj6evLTw3w3L2s--OKSVIqat9J3WwrRCEVifQJdTKRmnfsl-psV73vTH1vpjaz3XveqpNeI_nMXbQI98ps81EfDpBJSFvtePqTwz_zvmWpGro_MEUt-mYg</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Raha, Dipali</creator><creator>Tortorella, Cinzia</creator><creator>Neri, Giuliano</creator><creator>Prasad, Anita</creator><creator>Raza, Bushra</creator><creator>Raskar, Ranu</creator><creator>Dubey, Rakhi</creator><creator>Sen, Nisarga</creator><creator>Macchi, Carlo</creator><creator>Malendowicz, Ludwick</creator><creator>Ahmad, M</creator><creator>Nussdorfer, Gastone</creator><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines</title><author>Raha, Dipali ; Tortorella, Cinzia ; Neri, Giuliano ; Prasad, Anita ; Raza, Bushra ; Raskar, Ranu ; Dubey, Rakhi ; Sen, Nisarga ; Macchi, Carlo ; Malendowicz, Ludwick ; Ahmad, M ; Nussdorfer, Gastone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-cc380ff3997d8b488d96a301b76851b29ee921a7cb3410812c98a4f475a5923b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenal Medulla - drug effects</topic><topic>Adrenal Medulla - metabolism</topic><topic>Alprenolol - administration & dosage</topic><topic>Alprenolol - pharmacology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - administration & dosage</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Captopril - administration & dosage</topic><topic>Captopril - pharmacology</topic><topic>Catecholamines - secretion</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epinephrine - secretion</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - pharmacology</topic><topic>Guinea Pigs</topic><topic>Hydrocortisone - blood</topic><topic>Hydrocortisone - secretion</topic><topic>In Vitro Techniques</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Norepinephrine - secretion</topic><topic>Paracrine Communication - drug effects</topic><topic>Paracrine Communication - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raha, Dipali</creatorcontrib><creatorcontrib>Tortorella, Cinzia</creatorcontrib><creatorcontrib>Neri, Giuliano</creatorcontrib><creatorcontrib>Prasad, Anita</creatorcontrib><creatorcontrib>Raza, Bushra</creatorcontrib><creatorcontrib>Raskar, Ranu</creatorcontrib><creatorcontrib>Dubey, Rakhi</creatorcontrib><creatorcontrib>Sen, Nisarga</creatorcontrib><creatorcontrib>Macchi, Carlo</creatorcontrib><creatorcontrib>Malendowicz, Ludwick</creatorcontrib><creatorcontrib>Ahmad, M</creatorcontrib><creatorcontrib>Nussdorfer, Gastone</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raha, Dipali</au><au>Tortorella, Cinzia</au><au>Neri, Giuliano</au><au>Prasad, Anita</au><au>Raza, Bushra</au><au>Raskar, Ranu</au><au>Dubey, Rakhi</au><au>Sen, Nisarga</au><au>Macchi, Carlo</au><au>Malendowicz, Ludwick</au><au>Ahmad, M</au><au>Nussdorfer, Gastone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>17</volume><issue>4</issue><spage>633</spage><epage>636</epage><pages>633-636</pages><issn>1107-3756</issn><eissn>1791-244X</eissn><abstract>Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed,
along with its receptors, in organs and body tissues. ANP is well known to inhibit
aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone
production is controversial. In vivo experiments showed that prolonged ANP administration
raised the plasma concentration of cortisol in both normal and dexamethasone/captopril-treated
guinea pigs (i.e. in animals with pharmacologically interrupted hypothalamic-pituitary-adrenal
axis and renin-angiotensin system). ANP did not affect cortisol secretion from
dispersed guinea pig zona fasciculata-reticularis cells, but enhanced catecholamine
release from adrenomedullary cells. ANP stimulated cortisol output from guinea
pig adrenal slices containing medullary chromaffin tissue, and the β-adrenoceptor
antagonist l-alprenolol blocked this effect. The conclusion is drawn that ANP,
when the structural integrity of the adrenal gland is preserved, is able to enhance
glucocorticoid secretion in guinea pigs, through an indirect mechanism involving
the rise in the catecholamine release, which in turn, acting in a paracrine manner,
stimulate secretion of inner adrenocortical cells.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>16525720</pmid><doi>10.3892/ijmm.17.4.633</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1107-3756 |
| ispartof | International journal of molecular medicine, 2006-04, Vol.17 (4), p.633-636 |
| issn | 1107-3756 1791-244X |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenal Medulla - drug effects Adrenal Medulla - metabolism Alprenolol - administration & dosage Alprenolol - pharmacology Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Atrial Natriuretic Factor - administration & dosage Atrial Natriuretic Factor - pharmacology Captopril - administration & dosage Captopril - pharmacology Catecholamines - secretion Dexamethasone - administration & dosage Dexamethasone - pharmacology Dose-Response Relationship, Drug Epinephrine - secretion Female Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Guinea Pigs Hydrocortisone - blood Hydrocortisone - secretion In Vitro Techniques Injections, Subcutaneous Male Norepinephrine - secretion Paracrine Communication - drug effects Paracrine Communication - physiology |
| title | Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines |
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