Genetic Variations in Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase and Their Contributions to Human Disease

This review addresses a rapidly growing area of vascular biology, i.e. genomic variations in vascular genes that underlie different human phenotypes. Two of the most important molecular in vascular biology, endothelial nitric oxide synthase (eNOS) and vascular endothelial cell growth factor (VEGF) a...

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Bibliographic Details
Published in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2005-01, Vol.12 (1), p.129-140
Main Author: GERRITSEN, MARY E.
Format: Article
Language:English
Subjects:
atherosclerosis
Cardiovascular Diseases - genetics
Genetic Variation
genomics
Humans
hypertension
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type III
psoriasis
vascular disease
Vascular Endothelial Growth Factor A - genetics
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Summary:This review addresses a rapidly growing area of vascular biology, i.e. genomic variations in vascular genes that underlie different human phenotypes. Two of the most important molecular in vascular biology, endothelial nitric oxide synthase (eNOS) and vascular endothelial cell growth factor (VEGF) are discussed. Variations in the eNOS gene have been correlated with a number of human diseases including hypertension, coronary vasospasm, smoking dependent risk of coronary disease, myocardial infarction and placental disruption. Similarly, variations in the VEGF gene have been associated with increased risk of various cancers, DiGeorge syndrome, psoriasis, diabetic renal disease and amyotropic lateral sclerosis. Understanding the molecular basis of these genetic variations and how contribute to the pathophysiology provides new and important insights into human disease.
ISSN:1073-9688
1549-8719
DOI:10.1080/10739680590896081