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Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids

Complex small‐molecule libraries were constructed by a convergent approach with a short linear sequence: a 480‐membered bridged‐piperidine/fused‐pyrrolidine hybrid library IV and a 384‐membered spirocyclic‐oxindole/fused‐pyrrolidine hybrid library V from the sublibrary II and the sublibraries I and...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-04, Vol.44 (15), p.2249-2252
Main Authors: Chen, Chuo, Li, Xiaodong, Neumann, Christopher S., Lo, Michael M.-C., Schreiber, Stuart L.
Format: Article
Language:English
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Summary:Complex small‐molecule libraries were constructed by a convergent approach with a short linear sequence: a 480‐membered bridged‐piperidine/fused‐pyrrolidine hybrid library IV and a 384‐membered spirocyclic‐oxindole/fused‐pyrrolidine hybrid library V from the sublibrary II and the sublibraries I and III, respectively. II=RIICOOH.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200462798