Head-to-Tail Peptide Cyclodimerization by Copper-Catalyzed Azide-Alkyne Cycloaddition

Rings forged with copper: Oligopeptide cyclodimerization occurs selectively when precursors containing azide and alkyne groups are exposed to copper(I) ions on polystyrene supports (see picture; Prot=protecting group).

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-04, Vol.44 (15), p.2215-2220
Main Authors: Punna, Sreenivas, Kuzelka, Jane, Wang, Qian, Finn, M. G.
Format: Article
Language:English
Subjects:
alkynes
Alkynes - chemistry
Amino Acid Sequence
azides
Azides - chemistry
Catalysis
Copper - chemistry
Cyclization
cycloaddition
Dimerization
Molecular Sequence Data
Molecular Structure
peptides
Peptides - chemistry
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Description
Summary:Rings forged with copper: Oligopeptide cyclodimerization occurs selectively when precursors containing azide and alkyne groups are exposed to copper(I) ions on polystyrene supports (see picture; Prot=protecting group).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200461656