How to Interpret a Deterioration of Split Function?

• Published in: European urology 2005-05, Vol.47 (5), p.686-690
• Main Authors: Piepsz, A., Ismaili, K., Hall, M., Collier, F., Tondeur, M., Ham, H.
• Format: Article
• Language: English
• Subjects: Chelating Agents - pharmacokinetics; Child; Child, Preschool; Cr-51 EDTA; Disease Progression; Edetic Acid - pharmacokinetics; Follow-Up Studies; Glomerular Filtration Rate - physiology; Humans; Hydronephrosis - diagnostic imaging; Hydronephrosis - physiopathology; Hydronephrosis - urine; Infant; Kidney - diagnostic imaging; Kidney - physiopathology; Kidney Function Tests; Kidney Tubules, Proximal - diagnostic imaging; Kidney Tubules, Proximal - physiopathology; Radioisotope Renography - methods; Radiopharmaceuticals; Retrospective Studies; SKGFR; Split function; Tc-99m MAG3; Technetium Tc 99m Mertiatide
• ISSN: 0302-2838; 1873-7560
• DOI: 10.1016/j.eururo.2004.10.028

A drop of split renal function often constitutes a criterion for pyeloplasty in hydronephrosis since it is considered as representing deterioration of the affected kidney. The aim of this work was to determine, in a selected population of patients with a drop of split function of at least 5%, if the evolution of single kidney glomerular filtration rate (SKGFR) was parallel to the one of split renal function. From a large data basis, we found retrospectively only 29 children (10 below and 19 above two years of age at first examination) having had at least two Tc-99m mertiatide (Tc-99m MAG3) renographic explorations for various urological diseases, with a decrease of split function of at least 5% between the two examinations. Evolution of split function was compared to evolution of SKGFR obtained by means of the combination of Tc-99m MAG3 split function and overall glomerular filtration rate as given by the chromium Cr 51 ethylenediamine tetraacetic acid (EDTA) clearance. For the group above two years of age, SKGFR increased or remained stable in 63% of the cases, while in the children less than 2 years of age, a decrease of SKGFR was never observed, according to the maturation of overall GFR in this age group. Thus, the decrease of split function was not necessarily associated with a similar decrease of SKGFR. In patients with unilateral or bilateral urological disorders, deterioration of split renal function does not necessary correspond to a loss of function of the affected kidney. SKGFR often modifies the interpretation of split function.