Dendrimers:  Novel Polymeric Nanoarchitectures for Solubility Enhancement

Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug delivery and formulation development. Apart from conventional methods of solubility enhancement, there are some novel methods which can be used in solubilization. Dendrimers represent a novel type of pol...

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Bibliographic Details
Published in:Biomacromolecules 2006-03, Vol.7 (3), p.649-658
Main Authors: Gupta, Umesh, Agashe, Hrushikesh Bharat, Asthana, Abhay, Jain, N. K
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Dendrimers - chemistry
Drug Delivery Systems
Drug Design
Exact sciences and technology
General pharmacology
Hydrogen Bonding
Ions
Macromolecular Substances - chemistry
Medical sciences
Micelles
Nanostructures
Nanotechnology - methods
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polymers - chemistry
Properties and characterization
Solubility
Solution and gel properties
Surface Properties
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Summary:Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug delivery and formulation development. Apart from conventional methods of solubility enhancement, there are some novel methods which can be used in solubilization. Dendrimers represent a novel type of polymeric material that has generated much interest in many diverse areas due to their unique structure and properties. Dendrimer-mediated solubility enhancement mainly depends on factors such as generation size, dendrimer concentration, pH, core, temperature, and terminal functionality. Added advantage in solubilization can be achieved considering these factors. Available literature suggests that ionic interaction, hydrogen bonding, and hydrophobic interactions are the possible mechanisms by which a dendrimer exerts its solubilizing property. This review presents various mechanisms and reports relating to solubility enhancement using dendrimers. Also, micellar behavior and future possibilities in relation to solubilization via dendrimers are included.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm050802s