Diagnostic accuracy of multislice computed tomography coronary angiography is improved at low heart rates

Assess the effect of heart rate on diagnostic accuracy for the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). About 120 patients (105 males; 59+/-11 years) with suspected coronary artery disease who underwent conventional coronary angiography (C...

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Bibliographic Details
Published in:International Journal of Cardiovascular Imaging 2006-02, Vol.22 (1), p.101-105
Main Authors: Cademartiri, Filippo, Mollet, Nico R, Runza, Giuseppe, Belgrano, Manuel, Malagutti, Patrizia, Meijboom, Bob W, Midiri, Massimo, Feyter, Pim J de, Krestin, Gabriel P
Format: Article
Language:English
Subjects:
Chi-Square Distribution
Contrast Media
Coronary Angiography - methods
Coronary Disease - diagnostic imaging
Coronary Disease - physiopathology
Female
Heart Rate - physiology
Humans
Male
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Tomography, X-Ray Computed
Triiodobenzoic Acids
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Summary:Assess the effect of heart rate on diagnostic accuracy for the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). About 120 patients (105 males; 59+/-11 years) with suspected coronary artery disease who underwent conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. Patients underwent a MSCT-CA (Sensation 16, Siemens, Germany), with the following protocol: collimation 16 x 0.75 mm, gantry rotation time 420 ms, feed/rotation 3.0 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of Iodixanol (Visipaque 320 mg l/ml, Amersham, UK) at 4 ml/s and the delay was defined with a bolus tracking technique. In all patients the mean heart rate (HR) during the scan was used as a criteria to divide the population in two groups of 60 patients each. In one group (Low HR) the 60 patients with lower heart rates, and in the other group (High HR) the patients with higher heart rates. In the two groups diagnostic accuracy (per coronary segment) for the detection of significant stenosis (>or=50% lumen reduction) was evaluated in vessels >or=2 mm of diameter using quantitative CA as reference standard. The difference in diagnostic accuracy were compared with a Chi(2) test and a p
ISSN:1569-5794
1573-0743
DOI:10.1007/s10554-005-9010-6