The dynamics of LPS recognition: complex orchestration of multiple receptors

The molecular mechanisms that have been designed to protect the host from invading pathogens are responsible for sepsis, an often fatal response of the immune system against microbial pathogens. In the past few years, intense research in the field of innate immunity has identified a plethora of patt...

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Bibliographic Details
Published in:Journal of endotoxin research 2005-01, Vol.11 (1), p.5-11
Main Authors: Triantafilou, Martha, Triantafilou, Kathy
Format: Article
Language:English
Subjects:
Animals
Cytokines - secretion
Humans
Immunity, Innate
Lipopolysaccharide Receptors - metabolism
Lipopolysaccharides - immunology
Membrane Glycoproteins - immunology
Models, Biological
Protein Conformation
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - immunology
Receptors, Immunologic - immunology
Signal Transduction
Toll-Like Receptors
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Summary:The molecular mechanisms that have been designed to protect the host from invading pathogens are responsible for sepsis, an often fatal response of the immune system against microbial pathogens. In the past few years, intense research in the field of innate immunity has identified a plethora of pattern recognition receptors that are responsible for bacterial-induced activation. Recognition of bacterial lipopolysaccharide seems to involve a complex orchestration of protein-protein interactions that eventually leads to cellular activation. In this review, we attempt to unravel the dynamic interactions that occur among the different receptors involved and dictate the outcome of the innate immune response.
ISSN:0968-0519
1743-2839
DOI:10.1179/096805105225006641