Axillary recurrence after a negative sentinel node biopsy for breast cancer: incidence and clinical significance

• Published in: Annals of surgical oncology 2005-01, Vol.12 (1), p.29-33
• Main Authors: Smidt, Marjolein L, Janssen, Caroline M M, Kuster, Deborah M, Bruggink, Erik D M, Strobbe, Luc J A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Axilla; Breast Neoplasms - epidemiology; Breast Neoplasms - pathology; Cohort Studies; False Negative Reactions; Female; Humans; Incidence; Lymphatic Metastasis - diagnosis; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Prognosis; Prospective Studies; Sentinel Lymph Node Biopsy - standards
• ISSN: 1068-9265
• DOI: 10.1007/s10434-004-1166-0

Sentinel lymph node biopsy (SLNB) carries the inherent risk of approximately 5% false-negative sampling. Undetected tumor-positive nodes of clinical importance are those that lead to axillary recurrence. This survey aims at clarifying the extent of this problem in current practice and literature. In a regional teaching hospital, 696 consecutive breast cancer patients underwent SLNB between January 1998 and July 2003, and data were entered in a prospective database. PubMed and the Cochrane library were searched for a systematic review of the literature. Thirteen studies dealt with the follow-up of a cohort of sentinel lymph node (SLN)-negative patients or presented a case report. The SLN identification rate was 97.1%. The SLN was tumor free in 439 (65%) of the 676 patients. After a median follow-up of 26 months, axillary recurrence was detected in 2 of 439 patients 4 and 27 months after the SLNB. The incidence of clinically apparent false-negative SLNB is .46%. The systematic review resulted in 3184 SLNB-negative patients with a median follow-up of 25 months. Axillary recurrence occurred in eight patients after a median of 21 months. The axillary recurrence rate in the literature is .25%. One third of these patients present with synchronous systemic metastases. Axillary recurrences after a negative SLNB occur, but at a much lower rate than would be expected on the basis of historical figures and the false-negative SLN findings. The natural history of axillary relapse after negative SLNB resembles the locoregional recurrence of breast cancer.