Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis

Fifteen multiple sclerosis patients were examined by diffusion tensor imaging (DTI) to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in a superventricular volume of interest of 8 x 8 x 2 cm(3) containing gray matter (GM) and white matter (WM) tissue. Point resolved sp...

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Bibliographic Details
Published in:European radiology 2006-04, Vol.16 (4), p.898-904
Main Authors: Sijens, Paul E, Irwan, Roy, Potze, Jan Hendrik, Mostert, Jop P, De Keyser, Jacques, Oudkerk, Matthijs
Format: Article
Language:English
Subjects:
Anisotropy
Body Water - metabolism
Brain
Brain - metabolism
Chemical equilibrium
Diffusion coefficient
Diffusion Magnetic Resonance Imaging
Female
Humans
Linear Models
Magnetic resonance imaging
Male
Medical imaging
Middle Aged
Moisture content
Multiple sclerosis
Multiple Sclerosis - metabolism
Neuroimaging
Parameters
Spectroscopy
Substantia alba
Substantia grisea
Tensors
Water content
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Summary:Fifteen multiple sclerosis patients were examined by diffusion tensor imaging (DTI) to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in a superventricular volume of interest of 8 x 8 x 2 cm(3) containing gray matter (GM) and white matter (WM) tissue. Point resolved spectroscopy 2D-chemical shift imaging of the same volume was performed without water suppression. The water contents and DTI parameters in 64 voxels of 2 cm(3) were compared. The water content was increased in patients compared with controls (GM: 244+/-21 vs. 194+/-10 a.u.; WM: 245+/-32 vs. 190+/-11 a.u.), FA decreased (GM: 0.226+/-0.038 vs. 0.270+/-0.020; WM: 0.337+/-0.044 vs. 0.402+/-0.011) and ADC increased [GM: 1134+/-203 vs. 899+/-28 (x10(-6) mm(2)/s); WM: 901+/-138 vs. 751+/-17 (x10(-6) mm(2)/s)]. Correlations of water content with FA and ADC in WM were strong (r=-0.68, P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-005-0033-0