Understanding mesenchymal cancer: the liposarcoma-associated FUS–DDIT3 fusion gene as a model

Chromosomal translocations entail the generation of gene fusions in mesenchymal tumors. Despite the successful identification of these specific and consistent genetic events, the nature of the intimate association between the gene fusion and the resulting phenotype still remains to be elucidated. He...

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Bibliographic Details
Published in:Seminars in cancer biology 2005-06, Vol.15 (3), p.206-214
Main Authors: Pérez-Mancera, P.A., Sánchez-García, I.
Format: Article
Language:English
Subjects:
Adipocyte development
Animals
Cancer target cell
FUS–DDIT3
Humans
Liposarcoma
Liposarcoma - genetics
Liposarcoma - metabolism
Liposarcoma - pathology
Mesoderm - metabolism
Mesoderm - pathology
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oncogene Proteins, Fusion - genetics
Oncogene Proteins, Fusion - metabolism
RNA-Binding Protein FUS - genetics
RNA-Binding Protein FUS - metabolism
Solid tumors
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Summary:Chromosomal translocations entail the generation of gene fusions in mesenchymal tumors. Despite the successful identification of these specific and consistent genetic events, the nature of the intimate association between the gene fusion and the resulting phenotype still remains to be elucidated. Here these studies are reviewed, using FUS–DDIT3 as a model to illustrate how they have contributed to current understanding in unique and unexpected ways. FUS–DDIT3 is a chimeric oncogene generated by the most common chromosomal translocation t(12;16)(q13;p11) associated with liposarcomas. The application of transgenic methods to the study of this sarcoma-associated FUS–DDIT3 gene fusion has provided insights into their functions in vivo, and suggested mechanisms by which lineage selection may be achieved.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2005.01.006