Optical Probes for Biological Applications Based on Surface-Enhanced Raman Scattering from Indocyanine Green on Gold Nanoparticles

We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spati...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2005-04, Vol.77 (8), p.2381-2385
Main Authors: Kneipp, Janina, Kneipp, Harald, Rice, William L, Kneipp, Katrin
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Applied sciences
Biochemistry
Carcinoma - pathology
Cellular biology
Exact sciences and technology
Global environmental pollution
Gold Colloid - pharmacokinetics
Indocyanine Green - chemistry
Male
Metal Nanoparticles
Nanoparticles
Optics and Photonics - instrumentation
Pollution
Prostatic Neoplasms - pathology
Rats
Sensitivity and Specificity
Silver
Spectrum Analysis, Raman - instrumentation
Spectrum Analysis, Raman - methods
Surface Properties
Tumor Cells, Cultured
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Summary:We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spatially localized chemical information from its biological environment by employing SERS in the local optical fields of the gold nanoparticles. The probe offers the potential to increase the spectral specificity and selectivity of current chemical characterization approaches of living cells and biomaterials based on vibrational information.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac050109v